Predictive biomarkers: a paradigm shift towards personalized cancer medicine
NB La Thangue, DJ Kerr - Nature reviews Clinical oncology, 2011 - nature.com
Advances in our understanding of the intricate molecular mechanisms for transformation of a
normal cell to a cancer cell, and the aberrant control of complementary pathways, have …
normal cell to a cancer cell, and the aberrant control of complementary pathways, have …
Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing
FS Ong, K Das, J Wang, H Vakil, JZ Kuo… - Expert review of …, 2012 - Taylor & Francis
In the field of oncology, clinical molecular diagnostics and biomarker discoveries are
constantly advancing as the intricate molecular mechanisms that transform a normal cell into …
constantly advancing as the intricate molecular mechanisms that transform a normal cell into …
Biomarkers for personalized oncology: recent advances and future challenges
M Kalia - Metabolism, 2015 - Elsevier
Cancer is a group of diseases characterized by the uncontrolled growth and spread of
abnormal cells and oncology is a branch of medicine that deals with tumors. The last decade …
abnormal cells and oncology is a branch of medicine that deals with tumors. The last decade …
Predictive and prognostic molecular markers for cancer medicine
S Mehta, A Shelling, A Muthukaruppan… - … in medical oncology, 2010 - journals.sagepub.com
Over the last 10 years there has been an explosion of information about the molecular
biology of cancer. A challenge in oncology is to translate this information into advances in …
biology of cancer. A challenge in oncology is to translate this information into advances in …
Methodological and practical challenges for personalized cancer therapies
II Wistuba, JG Gelovani, JJ Jacoby, SE Davis… - Nature reviews Clinical …, 2011 - nature.com
Many experts agree that personalized cancer medicine, defined here as treatment based on
the molecular characteristics of a tumor from an individual patient, has great potential in the …
the molecular characteristics of a tumor from an individual patient, has great potential in the …
Integrating predictive biomarkers and classifiers into oncology clinical development programmes
The future of drug development in oncology lies in identifying subsets of patients who will
benefit from particular therapies, using predictive biomarkers. These technologies offer hope …
benefit from particular therapies, using predictive biomarkers. These technologies offer hope …
Biomarkers in cancer staging, prognosis and treatment selection
JA Ludwig, JN Weinstein - Nature Reviews Cancer, 2005 - nature.com
Advances in genomics, proteomics and molecular pathology have generated many
candidate biomarkers with potential clinical value. Their use for cancer staging and …
candidate biomarkers with potential clinical value. Their use for cancer staging and …
Clinical trial designs for evaluating the medical utility of prognostic and predictive biomarkers in oncology
R Simon - Personalized medicine, 2010 - Taylor & Francis
Physicians need improved tools for selecting treatments for individual patients. Many
diagnostic entities hat were traditionally viewed as individual diseases are heterogeneous in …
diagnostic entities hat were traditionally viewed as individual diseases are heterogeneous in …
Cancer biomarkers: selecting the right drug for the right patient
GJ Kelloff, CC Sigman - Nature reviews Drug discovery, 2012 - nature.com
This Perspective highlights biomarkers that are expressed as a consequence of cancer
development and progression. We focus on those biomarkers that are most relevant for …
development and progression. We focus on those biomarkers that are most relevant for …
Predicting clinical outcomes using molecular biomarkers
HB Burke - Biomarkers in cancer, 2016 - journals.sagepub.com
Over the past 20 years, there has been an exponential increase in the number of
biomarkers. At the last count, there were 768,259 papers indexed in PubMed. gov directly …
biomarkers. At the last count, there were 768,259 papers indexed in PubMed. gov directly …
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