Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …

Cancer is a complex pathology that causes a large number of deaths worldwide. Several
risk factors are involved in tumor transformation, including epigenetic factors. These factors …

Histone deacetylases (HDACs) play a key role in the homeostasis of protein acetylation in
histones and have recently emerged as a therapeutic target for numerous diseases. The …

Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Protein acetylation status results from a balance between histone acetyltransferase and
histone deacetylase (HDAC) activities. Alteration of this balance leads to a disruption of …

Acetylation is an important, reversible post-translational modification affecting histone and
non-histone proteins with critical roles in gene transcription, DNA replication, DNA repair …

Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …

Epigenetic modifications such as histone modification play an important role in
tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key …

Introduction: Histone deacetylase (HDAC) inhibitors play a crucial role in restoring the
balance of acetylation and deacetylation of lysine residues of histones and non-histone …