Targeting histone deacetylases with natural and synthetic agents: an emerging anticancer strategy
Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …
Acetylation-mediated histone/non-histone protein modification plays an important role in the …
Natural bioactive compounds targeting histone deacetylases in human cancers: recent updates
Cancer is a complex pathology that causes a large number of deaths worldwide. Several
risk factors are involved in tumor transformation, including epigenetic factors. These factors …
risk factors are involved in tumor transformation, including epigenetic factors. These factors …
From natural products to HDAC inhibitors: An overview of drug discovery and design strategy
X Qiu, L Zhu, H Wang, Y Tan, Z Yang, L Yang… - Bioorganic & Medicinal …, 2021 - Elsevier
Histone deacetylases (HDACs) play a key role in the homeostasis of protein acetylation in
histones and have recently emerged as a therapeutic target for numerous diseases. The …
histones and have recently emerged as a therapeutic target for numerous diseases. The …
Roles of histone deacetylases and inhibitors in anticancer therapy
Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …
The roles of histone deacetylases and their inhibitors in cancer therapy
G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
Histone deacetylase modulators provided by Mother Nature
Protein acetylation status results from a balance between histone acetyltransferase and
histone deacetylase (HDAC) activities. Alteration of this balance leads to a disruption of …
histone deacetylase (HDAC) activities. Alteration of this balance leads to a disruption of …
Histone and non-histone targets of dietary deacetylase inhibitors
E Kim, WH Bisson, CV Lohr… - Current topics in …, 2016 - ingentaconnect.com
Acetylation is an important, reversible post-translational modification affecting histone and
non-histone proteins with critical roles in gene transcription, DNA replication, DNA repair …
non-histone proteins with critical roles in gene transcription, DNA replication, DNA repair …
Targeting histone deacetylases for cancer therapy: Trends and challenges
T Liang, F Wang, RM Elhassan, Y Cheng… - … Pharmaceutica Sinica B, 2023 - Elsevier
Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …
progression. As promising anticancer targets, HDACs have gained a great deal of research …
[HTML][HTML] Histone deacetylases and histone deacetylase inhibitors: molecular mechanisms of action in various cancers
Epigenetic modifications such as histone modification play an important role in
tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key …
tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key …
Histone deacetylase (HDAC) inhibitors in cancer: a patent review (2017-present)
C Zhao, H Dong, Q Xu, Y Zhang - Expert opinion on therapeutic …, 2020 - Taylor & Francis
Introduction: Histone deacetylase (HDAC) inhibitors play a crucial role in restoring the
balance of acetylation and deacetylation of lysine residues of histones and non-histone …
balance of acetylation and deacetylation of lysine residues of histones and non-histone …
相关搜索
- cancer therapy histone deacetylases
- anticancer strategy histone deacetylases
- selective inhibitors histone deacetylase
- molecular mechanisms histone deacetylases
- trends and challenges histone deacetylases
- design strategy natural products
- various cancers histone deacetylases
- anticancer therapy histone deacetylases
- human cancers histone deacetylases