Monoaminergic neurons located in the central nervous system (CNS) are organized into
complex circuits which include noradrenergic (NA), adrenergic (Ad), dopaminergic (DA) …

A review of the anatomic organization of ascending serotonin projections is followed by
recent findings showing that these axonal projections are not diffuse but have an intricate …

Abstract Neurotransmission by serotonin (5-HT) is tightly regulated by several autoreceptors
that fine-tune serotonergic neurotransmission through negative feedback inhibition at the …

Serotonin neurons in the rostral and caudal brainstem raphe nuclear groups give rise to
collateralized ascending and descending projections which provide modulatory input into …

The serotonergic system arising from the dorsal raphe nucleus (DR) has long been
implicated in psychiatric disorders, and is considered one site of action of classical anxiolytic …

Rationale Dysfunction of serotonergic systems is thought to play an important role in a
number of neurological and psychiatric disorders. Recent studies suggest that there is …

Serotonergic systems play an important and generalized role in regulation of sleep‐wake
states and behavioral arousal. Recent in vivo electrophysiologic recording studies in …

Over 20 years ago, Deakin and Graeff hypothesized about the role of different serotonergic
pathways in controlling the behavioral and physiologic responses to aversive stimuli, and …

The dorsal raphe nucleus (DRN) projects serotonergic axons throughout the brain and is
involved in a variety of physiological functions. However, it also includes a large population …

Depressed suicide patients have elevated expression of neuronal tryptophan hydroxylase 2
(TPH2) mRNA and protein in midbrain serotonergic neurons, as well as increases in brain …