Abstract Analysis of DNA methylation is a valuable tool to understand disease progression
and is increasingly being used to create diagnostic and prognostic clinical biomarkers …

A critical need in understanding the biology of prostate cancer is characterizing the
molecular differences between indolent and aggressive cases. Because DNA methylation …

Transcriptional deregulation of oncogenic pathways is a hallmark of cancer and can be due
to epigenetic alterations. 5-Hydroxymethylcytosine (5-hmC) is an epigenetic modification …

Background Prognostic tools for prostate cancer (PC) are inadequate and new molecular
biomarkers may improve risk stratification. The epigenetic mark 5-hydroxymethylcytosine …

Early detection and characterization of molecular events associated with tumorgenesis
remain high priorities. Genome-wide epigenetic assays are promising diagnostic tools, as …

Background Prostate cancer (PC) can be stratified into distinct molecular subtypes based on
TMPRSS2-ERG gene fusion status, but its potential prognostic value remains controversial …

Background Despite the significant global loss of DNA hydroxymethylation marks in prostate
cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is …

Hydroxymethylcytosine (5hmC) is an important mammalian DNA epigenetic modification
that has been linked to gene regulation and cancer pathogenesis. Here we explored the …

Background Growing evidence indicates that methylation status is associated with the
pathogenesis of numerous types of cancers. Among these, hepatocellular carcinoma (HCC) …

The clinical heterogeneity of prostate cancer (PCa) makes it difficult to identify those patients
that could benefit from more aggressive treatments. As a contribution to a better …