BAFF-driven autoimmunity requires CD19 expression

KA Fairfax, E Tsantikos, WA Figgett, FB Vincent… - Journal of …, 2015 - Elsevier
B cell activating factor of the tumor necrosis factor family (BAFF or BLyS) is a critical factor for
B cell survival and maturation. BAFF-transgenic (BAFF-Tg) mice develop autoimmunity that …

Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice

CA Fletcher, JR Groom, B Woehl, H Leung… - Journal of …, 2011 - Elsevier
B cell activating factor belonging to the TNF family (BAFF or BLyS) is a critical B cell survival
factor essential for B cell maturation. BAFF transgenic (Tg) mice develop autoimmunity …

Development of nephritis but not sialadenitis in autoimmune‐prone BAFF transgenic mice lacking marginal zone B cells

CA Fletcher, APR Sutherland, JR Groom… - European journal of …, 2006 - Wiley Online Library
B cell-activating factor belonging to the TNF family (BAFF, also termed BLyS, TALL-1, zTNF-
4, THANK, and TNFSF13b) has emerged as a cytokine critical for peripheral B cell survival …

Promotion of T regulatory cells in mice by B cells and BAFF

W Stohl, N Yu - The Journal of Immunology, 2020 - journals.aai.org
In addition to promoting B cell expansion, overexpression of BAFF promotes expansion of T
cells, including T regulatory (Treg) cells. To determine the relationships among BAFF, B …

BAFF augments certain Th1-associated inflammatory responses

APR Sutherland, LG Ng, CA Fletcher… - The Journal of …, 2005 - journals.aai.org
B cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of B
cell maturation and survival, and its overexpression in BAFF transgenic (Tg) mice results in …

The role of BAFF in immune function and implications for autoimmunity

SL Kalled - Immunological reviews, 2005 - Wiley Online Library
BAFF [B‐cell activating factor belonging to the tumor necrosis factor (TNF) family] is a ligand
that is required for peripheral B‐cell survival and homeostasis. In addition to mediating B …

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome

J Groom, SL Kalled, AH Cutler, C Olson… - The Journal of …, 2002 - Am Soc Clin Investig
BAFF (BLyS, TALL-1, THANK, zTNF4) is a member of the TNF superfamily that specifically
regulates B lymphocyte proliferation and survival. Mice transgenic (Tg) for BAFF develop an …

Cracking the BAFF code

F Mackay, P Schneider - Nature reviews immunology, 2009 - nature.com
The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL
(a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess …

BAFF: a local and systemic target in autoimmune diseases

I Moisini, A Davidson - Clinical & Experimental Immunology, 2009 - academic.oup.com
BAFF (B lymphocyte activating factor of the tumour necrosis factor family) is a vital
homeostatic cytokine for B cells that helps regulate both innate and adaptive immune …

Integrated B cell, Toll-like, and BAFF receptor signals promote autoantibody production by transitional B cells

SW Du, HM Jacobs, T Arkatkar… - The Journal of …, 2018 - journals.aai.org
The B cell survival cytokine BAFF has been linked with the pathogenesis of systemic lupus
erythematosus (SLE). BAFF binds distinct BAFF-family surface receptors, including the BAFF …