Melatonin and cisplatin co-treatment against cancer: a mechanistic review of their synergistic effects and melatonin's protective actions

M Rafiyan, A Davoodvandi, RJ Reiter… - … -Research and Practice, 2023 - Elsevier
Combination chemotherapy appears to be a preferable option for some cancer patients,
especially when the medications target multiple pathways of oncogenesis; individuals …

Melatonin as an adjuvant treatment modality with doxorubicin

PM Dana, F Sadoughi, RJ Reiter, S Mohammadi… - Biochimie, 2022 - Elsevier
Combination chemotherapy seems to be a beneficial choice for some cancer patients
particularly when the drugs target different processes of oncogenesis; patients treated with …

Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy

A Mafi, M Rezaee, N Hedayati, SD Hogan… - Cell Communication and …, 2023 - Springer
Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials

Y Wang, B Jin, F Ai, C Duan, Y Lu, T Dong… - Cancer chemotherapy and …, 2012 - Springer
Background Recently, melatonin has been associated with cancer both in vitro and in vivo.
However, the value of melatonin in the treatment of cancer remains disputable. Hence, we …

Adjuvant chemotherapy with melatonin for targeting human cancers: A review

M Najafi, E Salehi, B Farhood… - Journal of cellular …, 2019 - Wiley Online Library
Melatonin is a multifunctional hormone that has long been known for its antitumoral effects.
An advantage of the application of melatonin in cancer therapy is its ability to differentially …

Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status

P Lissoni, S Barni, M Mandala, A Ardizzoia… - European Journal of …, 1999 - Elsevier
Melatonin (MLT) has been proven to counteract chemotherapy toxicity, by acting as an anti-
oxidant agent, and to promote apoptosis of cancer cells, so enhancing chemotherapy …

Melatonin in patients with cancer receiving chemotherapy: A randomized, double-blind, placebo-controlled trial

A Sookprasert, NP Johns, A Phunmanee… - Anticancer …, 2014 - ar.iiarjournals.org
Background: The MIRCIT trial was a randomized, double-blind, placebo-controlled study of
advanced Non-small cell lung cancer (NSCLC). Patients and Methods: Patients were …

Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms

P Lissoni - Pathologie Biologie, 2007 - Elsevier
It is known since many years that the pineal hormone melatonin (MLT) may play anticancer
activity through several mechanisms, including antiproliferative and immunostimulating …

Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis

Y Wang, P Wang, X Zheng, X Du - OncoTargets and therapy, 2018 - Taylor & Francis
Background Melatonin (MLT), a kind of neuroendocrine active substance, has been reported
to function in the treatment of tumors. However, there remain controversies about the …

Melatonin: Avenues in cancer therapy and its nanotechnological advancements

CL Putta, K Eswar, AK Rengan - MedComm–Biomaterials and …, 2023 - Wiley Online Library
Cancer is one of the most prevailing causes of mortality worldwide. Standard therapies for
cancer patients include surgical intervention, chemotherapy, and radiotherapy …