Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure
during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is …

Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-
interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase domain-like protein …

Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …

Regulated cell death is one major factor to ensure homoeostasis in multicellular organisms.
For decades, apoptosis was considered as the sole form of regulated cell death, whereas …

In the past few decades, apoptosis has been regarded as the only form of programmed cell
death. However, the traditional view has been challenged by the identification of several …

Necroptosis is a programmed, caspase-independent cell death that is morphologically
similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by …

One of the hallmarks of cancer is resistance to programmed cell death, which maintains the
survival of cells en route to oncogenic transformation and underlies therapeutic resistance …

While the mechanisms underlying apoptosis and autophagy have been well characterized
over recent decades, another regulated cell death event, necroptosis, remains poorly …

Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

Necroptosis is a caspase-independent form of programmed cell death executed by the
receptor interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kinase domain-like …