[HTML][HTML] Targeting cullin neddylation for cancer and fibrotic diseases
ZX He, W Yang, D Zengyangzong, G Gao, Q Zhang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …
Protein neddylation and its role in health and diseases
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
A review on cullin neddylation and strategies to identify its inhibitors for cancer therapy
The cullin-RING E3 ligases (CRLs) are the biggest components of the E3 ubiquitin ligase
protein family, and they represent an essential role in various diseases that occur because …
protein family, and they represent an essential role in various diseases that occur because …
[HTML][HTML] Anticancer drug discovery by targeting cullin neddylation
Q Yu, Y Jiang, Y Sun - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Protein neddylation is a post-translational modification which transfers the ubiquitin-like
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …
Targeting protein neddylation for cancer therapy
L Zhou, L Jia - Cullin-RING Ligases and Protein Neddylation: Biology …, 2020 - Springer
Neddylation is a posttranslational modification that conjugates a ubiquitin-like protein
NEDD8 to substrate proteins. The best-characterized substrates of neddylation are the cullin …
NEDD8 to substrate proteins. The best-characterized substrates of neddylation are the cullin …
Targeting DCN1-UBC12 protein-protein interaction for regulation of neddylation pathway
Protein neddylation is one type of posttranslational modifications that regulates the activity of
the substrate proteins. Neddylation modification is catalyzed by NEDD8-activating enzyme …
the substrate proteins. Neddylation modification is catalyzed by NEDD8-activating enzyme …
Targeting protein Neddylation to inactivate Cullin-RING ligases by Gossypol: a lucky hit or a new start?
Q Yu, Y Sun - Drug Design, Development and Therapy, 2021 - Taylor & Francis
Abstract Cullin-RING E3 ligases (CRLs) are the largest family of E3 ubiquitin ligases,
responsible for about 20% of the protein degradation by the ubiquitin-proteasome system …
responsible for about 20% of the protein degradation by the ubiquitin-proteasome system …
Deciphering the role of neddylation in tumor microenvironment modulation: common outcome of multiple signaling pathways
D Liu, X Che, G Wu - Biomarker Research, 2024 - Springer
Neddylation is a post-translational modification process, similar to ubiquitination, that
controls several biological processes. Notably, it is often aberrantly activated in neoplasms …
controls several biological processes. Notably, it is often aberrantly activated in neoplasms …
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
Significance: Protein neddylation is catalyzed by an E1 NEDD8-activating enzyme (NAE), an
E2 NEDD8-conjugating enzyme, and an E3 NEDD8 ligase. Known physiological substrates …
E2 NEDD8-conjugating enzyme, and an E3 NEDD8 ligase. Known physiological substrates …