Background: Colchicine has a narrow therapeutic index. Its toxicity can be increased due to
concomitant exposure to drugs inhibiting its metabolic pathway; these are cytochrome P450 …

Colchicine is useful for the prevention and treatment of gout and a variety of other disorders.
It is a substrate for CYP3A4 and P-glycoprotein (P-gp), and concomitant administration with …

The anti-inflammatory agent colchicine may cause toxic effects such as rhabdomyolysis,
pancytopenia, and acute respiratory distress syndrome in cases of overdose and when …

Study Objective As data that prompted a 2009 labeling change detailing contraindications,
precautions, and dosing recommendations for the first branded colchicine product were …

We are fortunate to live in an era with an expansive pharmacopeia, and more than 20 000
prescription drug products are currently approved by the US Food and Drug Administration …

Several randomized clinical trials have demonstrated the clinical utility of colchicine in the
prevention and management of various cardiovascular conditions, including secondary …

Colchicine is increasingly used as the number of potential indications expands. However, it
also has a narrow therapeutic index that is associated with bothersome to severe side …

Objective The use of colchicine has been associated with varying degrees of
myelosuppression. Despite expanded use in cardiovascular and inflammatory conditions …

Background. Colchicine is commonly used for the treatment of gout and occasionally for
other inflammatory diseases. It has a narrow therapeutic index and the potential for severe …

Colchicine has an important role in managing various conditions, including gout, familial
Mediterranean fever, amyloidosis, Behçet's syndrome, recurrent pericarditis and calcium …