Synthetic carbohydrate-based vaccines: challenges and opportunities

R Mettu, CY Chen, CY Wu - Journal of Biomedical Science, 2020 - Springer
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been
extremely successful in preventing bacterial infections. The glycan antigens for the …

Carbohydrate based vaccines

B Kuberan, RJ Linhardt - Current Organic Chemistry, 2000 - ingentaconnect.com
Vaccination is the most cost-efficient and the most powerful medical intervention in the
control, prevention and eradication of many diseases that affect human population. Capsular …

Antimicrobial glycoconjugate vaccines: an overview of classic and modern approaches for protein modification

F Berti, R Adamo - Chemical Society Reviews, 2018 - pubs.rsc.org
Glycoconjugate vaccines obtained by chemical linkage of a carbohydrate antigen to a
protein are part of routine vaccinations in many countries. Licensed antimicrobial glycan …

Recent advances in the production of recombinant glycoconjugate vaccines

E Kay, J Cuccui, BW Wren - npj Vaccines, 2019 - nature.com
Glycoconjugate vaccines against bacteria are one of the success stories of modern
medicine and have led to a significant reduction in the global occurrence of bacterial …

Development in the concept of bacterial polysaccharide repeating unit-based antibacterial conjugate vaccines

R Rohokale, Z Guo - ACS infectious diseases, 2023 - ACS Publications
The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

New trends in carbohydrate-based vaccines

R Roy - Drug discovery today: Technologies, 2004 - Elsevier
Carbohydrate-based vaccines constitute successful therapeutic arsenals against microbial
infections, particularly since the advent of bacterial capsular polysaccharide (CPS) protein …

Recent advances in carbohydrate-based vaccines

ML Hecht, P Stallforth, DV Silva, A Adibekian… - Current opinion in …, 2009 - Elsevier
Vaccinations provide an efficient and cost-effective way to combat devastating human
diseases. Besides pathogenic protein markers, cell surface carbohydrates from biological …

Discovery of semi-and fully-synthetic carbohydrate vaccines against bacterial infections using a medicinal chemistry approach: focus review

PH Seeberger - Chemical Reviews, 2021 - ACS Publications
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and
parasitic pathogens. Recognition of these unique glycans by the human immune system …

Potential targets for next generation antimicrobial glycoconjugate vaccines

F Micoli, P Costantino, R Adamo - FEMS microbiology reviews, 2018 - academic.oup.com
Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

Recent advances in the synthesis of glycoconjugates for vaccine development

C Colombo, O Pitirollo, L Lay - Molecules, 2018 - mdpi.com
During the last decade there has been a growing interest in glycoimmunology, a relatively
new research field dealing with the specific interactions of carbohydrates with the immune …