[HTML][HTML] High-fat diet induces apoptosis of hypothalamic neurons
Consumption of dietary fats is amongst the most important environmental factors leading to
obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic …
obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic …
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of …
M Milanski, G Degasperi, A Coope… - Journal of …, 2009 - Soc Neuroscience
In animal models of diet-induced obesity, the activation of an inflammatory response in the
hypothalamus produces molecular and functional resistance to the anorexigenic hormones …
hypothalamus produces molecular and functional resistance to the anorexigenic hormones …
[HTML][HTML] Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
S Jin, JG Kim, JW Park, M Koch, TL Horvath, BJ Lee - Scientific reports, 2016 - nature.com
Various pathophysiologic mechanisms leading to sickness behaviors have been proposed.
For example, an inflammatory process in the hypothalamus has been implicated, but the …
For example, an inflammatory process in the hypothalamus has been implicated, but the …
High-fat diet consumption alters energy metabolism in the mouse hypothalamus
Abstract Background/Objectives High-fat diet consumption is known to trigger an
inflammatory response in the hypothalamus, which has been characterized by an initial …
inflammatory response in the hypothalamus, which has been characterized by an initial …
[HTML][HTML] TLR4 links innate immunity and fatty acid–induced insulin resistance
TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4
activates proinflammatory pathways and induces cytokine expression in a variety of cell …
activates proinflammatory pathways and induces cytokine expression in a variety of cell …
TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation
Obesity is accompanied by the activation of low-grade inflammatory activity in metabolically
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
Obesity has reached epidemic proportions in several regions of the world. General changes
in lifestyle, including consumption of fat-rich food, are among the most important factors …
in lifestyle, including consumption of fat-rich food, are among the most important factors …
[HTML][HTML] Obesity is associated with hypothalamic injury in rodents and humans
Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by
inflammation both in peripheral tissues and in hypothalamic areas critical for energy …
inflammation both in peripheral tissues and in hypothalamic areas critical for energy …
Diet-induced inflammation of the hypothalamus in obesity
Dysfunction of specific hypothalamic neurons is regarded as an important mechanism
predisposing to the development of obesity. Recent studies have revealed that the …
predisposing to the development of obesity. Recent studies have revealed that the …
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
M Milanski, AP Arruda, A Coope, LM Ignacio-Souza… - Diabetes, 2012 - Am Diabetes Assoc
Defective liver gluconeogenesis is the main mechanism leading to fasting hyperglycemia in
type 2 diabetes, and, in concert with steatosis, it is the hallmark of hepatic insulin resistance …
type 2 diabetes, and, in concert with steatosis, it is the hallmark of hepatic insulin resistance …