Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

Hypoxic microenvironments frequently exist in many solid tumours with oxygen levels
fluctuating temporally and spatially from normoxia to hypoxia. The response to hypoxia in …

Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function,
but is also an important component of the tumour microenvironment as it alters the …

Solid tumors possess unique microenvironments that are exposed to chronic hypoxic
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects
ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and …

Hypoxia acts as an important regulator of physiological and pathological processes.
Hypoxia inducible factors (HIFs) are the central players involved in the cellular adaptation to …

Oxygen deprivation leading to hypoxia is a common feature of solid tumours. Under these
conditions a signalling pathway involving a key oxygen-response regulator termed the …

Hypoxic environments occur normally at high altitude, or in underground burrows and in
deep sea habitats. They also occur pathologically in human ischemia and in hypoxic solid …

Intratumoral heterogeneity is an important factor contributing to metastasis and therapy
resistance. The phenotypic diversity of cancer cells within the tumor microenvironment is …

A hypoxic microenvironment plays a critical role in the development and progression of
tumors. The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells …