Neurochemical evidence of preclinical and clinical reports on target-based therapy in alcohol used disorder

SK Prajapati, S Bhaseen, S Krishnamurthy… - Neurochemical …, 2020 - Springer
Alcohol use disorder (AUD) is a chronic relapsing disorder, which enforces a person to
compulsively seek alcohol, restricting control over alcohol intake leads to emergence of an …

Probing the Manipulated Neurochemical Drive in Alcohol Addiction and Novel Therapeutic Advancements

D Chouhan, A Uniyal, A Gadepalli… - ACS chemical …, 2020 - ACS Publications
Alcohol addiction is one of the highly prevalent neurological disorders and a major threat to
public health in the 21st century. Alcohol addiction affects people from all age groups and …

Alcohol use disorder: neurobiology and therapeutics

W Yang, R Singla, O Maheshwari, CJ Fontaine… - Biomedicines, 2022 - mdpi.com
Alcohol use disorder (AUD) encompasses the dysregulation of multiple brain circuits
involved in executive function leading to excessive consumption of alcohol, despite negative …

Targeting unmet clinical needs in the treatment of alcohol use disorder

FW Lohoff - Frontiers in Psychiatry, 2022 - frontiersin.org
Alcohol Use Disorder (AUD) is a chronic psychiatric disorder marked by impaired control
over drinking behavior that poses a significant challenge to the individual, their community …

Alcohol pharmacology and pharmacotherapy of alcoholism

A Upaganlawar, S Ramesh, E Jones… - Advances in …, 2020 - taylorfrancis.com
Ethanol, the most extensively used alcohol, is a resourceful, multipurpose molecule, with
different effects on various biological systems. Due to its relative easiness to synthesize …

Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependence

L Leggio, S Cardone, A Ferrulli… - Current …, 2010 - ingentaconnect.com
Treating alcohol use disorders represents a main goal in public health, but the effect of
current medications is modest. Thus, in the last few years, research has been focusing on …

Alcohol use disorder treatment: Problems and solutions

GF Koob - Annual Review of Pharmacology and Toxicology, 2024 - annualreviews.org
Alcohol use disorder (AUD) afflicts over 29 million individuals and causes more than
140,000 deaths annually in the United States. A heuristic framework for AUD includes a …

[HTML][HTML] The potential of neuroscience to inform treatment

GF Koob - Alcohol Research & Health, 2010 - ncbi.nlm.nih.gov
In the 40 years since the founding of the National Institute on Alcohol Abuse and Alcoholism
(NIAAA), researchers have gained a better understanding of the brain circuits and brain …

New approved and emerging pharmacological approaches to alcohol use disorder: a review of clinical studies

KC Morley, CJ Perry, J Watt, T Hurzeler… - Expert Opinion on …, 2021 - Taylor & Francis
Abstract introduction: The number of medications approved for AUD is small and they
generally have limited efficacy. We need new pharmacotherapies for the management of …

Consequences of alcohol consumption on neurotransmitters-an overview

S Mukherjee, SK Das, K Vaidyanathan… - Current …, 2008 - ingentaconnect.com
Alcohol one of the important products of the global addiction alters brain function by
interacting with multiple neurotransmitter systems, thereby disrupting the delicate balance …