Objective ANTHEM-HF evaluated a novel autonomic regulation therapy (ART) via either left
or right vagus nerve stimulation (VNS) in patients with heart failure (HF) and reduced …

Objective Evaluate the effects of a novel autonomic regulation therapy (ART) via vagus
nerve stimulation (VNS) in patients with chronic heart failure (HF) and reduced left …

Abstract Background The ANTHEM-HF pilot study was an open-label study that evaluated
the safety and feasibility of autonomic regulation therapy (ART) utilizing cervical vagus nerve …

Background Autonomic regulation therapy (ART) utilizing cervical vagus nerve stimulation
(VNS) appeared to be safe and to improve autonomic tone, symptoms, and cardiac …

Background Outcomes of heart failure (HF) have improved dramatically with the use of
blockers of the sympathetic and renin-angiotensin-aldosterone systems, as well as with …

Aims Clinical studies of vagal nerve stimulation (VNS) for heart failure with reduced ejection
fraction have had mixed results to date. We sought to compare VNS delivery and associated …

Background: Heart failure (HF) is increasing in prevalence and is a major cause of morbidity
and mortality despite advances in medical and device therapy. Autonomic imbalance, with …

Aim The neural cardiac therapy for heart failure (NECTAR-HF) was a randomized sham-
controlled trial designed to evaluate whether a single dose of vagal nerve stimulation (VNS) …

Aims In chronic heart failure (CHF), reduced vagal activity correlates with increased mortality
and acute decompensation. Experimentally, chronic vagus nerve stimulation (VNS) …

Abstract Background The NECTAR-HF study evaluated safety and feasibility of vagal nerve
stimulation (VNS) for the treatment of heart failure patients. The first six-month randomized …