Background Neuroinflammation has been widely accepted as a cause of the degenerative
process. Increasing interest has been devoted to developing intervening therapeutics for …

Recent emerging evidence reveals that cGAS-STING-mediated Type I interferon (IFN)
signaling axis takes part in the microglial-associated neuroinflammation. However, the …

Parkinson's disease (PD) is a neurodegenerative disease with unknown cause in the
majority of patients, who are therefore considered “idiopathic”(IPD). PD predominantly …

Background Microglial activation-mediated neuroinflammation plays an important role in the
progression of neurodegenerative diseases. Inflammatory activation of microglial cells is …

1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) intoxication in mice results in
dopamine neuron degeneration that is alleviated by prevention of microglia cell activation …

The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here,
we have investigated the role of peripheral inflammation induced by systemic …

Parkinson's disease (PD) is one of the prevalent neurodegenerative diseases associated
with preferential loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) …

Parkinson's disease (PD), the second most common neurodegenerative disorder, is
characterized by neuroinflammation, formation of Lewy bodies, and progressive loss of …

Background Reactive microglia have been associated with the histological changes that
occur in Parkinson's disease brains and mouse models of the disease. Multiple studies from …

DNA sensing is a pivotal component of the innate immune system that is responsible for
detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the …