Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term
newborns and currently has no cure. Inflammatory processes play a key role in the …

Hypoxic-ischemic encephalopathy (HIE) is a major cause of mortality and morbidity in
neonates, with an estimated global incidence of 3/1,000 live births. HIE brain damage is …

Cerebral ischemia-reperfusion (CIR) accelerates the progression of neurodegeneration by
causing mitochondrial dysfunction to overproduce reactive oxygen species (ROS). Curcumin …

Perinatal hypoxic–ischemic encephalopathy (HIE) can result in neurodevelopmental
disability, including cerebral palsy. The only treatment, hypothermia, provides incomplete …

Curcumin, a neuroprotective agent with promising therapeutic approach has poor brain
bioavailability. Herein, we demonstrate that curcumin-encapsulated poly (lactide-co …

Background Cerebral ischemia/reperfusion (I/R) injury contributes to mortality and morbidity
in preterm infants. Curcumin has been shown to exert neuro-protective effects in the central …

Intracerebral hemorrhage (ICH) represents one of the most severe subtypes of stroke. Due
to the complexity of the brain injury mechanisms following ICH, there are currently no …

Scope To evaluate curcumin loaded solid lipid nanoparticles (C-SLNs) in the experimental
paradigm of cerebral ischemia (BCCAO model) in rats. Methods and results Oral …

Stroke is a one of the leading causes of disease and deaths worldwide, which causes
irreversible deterioration of the central nervous system. Curcuminoids are reported to have a …

Oxidative stress and inflammatory damage play an important role in cerebral ischemic
pathogenesis and may represent a target for treatment. The development of new strategies …