Beyond Spirometry: Linking Wasted Ventilation to Exertional Dyspnea in the Initial Stages of COPD

JA Neder, G Santyr, B Zanette, M Kirby… - COPD: Journal of …, 2024 - Taylor & Francis
Exertional dyspnea, a key complaint of patients with chronic obstructive pulmonary disease
(COPD), ultimately reflects an increased inspiratory neural drive to breathe. In non …

Ventilatory inefficiency and exertional dyspnea in early chronic obstructive pulmonary disease

JA Neder, DC Berton, PT Müller… - Annals of the …, 2017 - atsjournals.org
Exertional dyspnea is present across the spectrum of chronic obstructive pulmonary disease
(COPD) severity. However, without realizing it themselves, patients may decrease daily …

[HTML][HTML] Exertional ventilation/carbon dioxide output relationship in COPD: from physiological mechanisms to clinical applications

JA Neder, DC Berton, DB Phillips… - European Respiratory …, 2021 - Eur Respiratory Soc
There is well established evidence that the minute ventilation (V′ E)/carbon dioxide output
(V′ CO 2) relationship is relevant to a number of patient-related outcomes in COPD. In most …

Exertional dyspnoea in patients with mild‐to‐severe chronic obstructive pulmonary disease: neuromechanical mechanisms

MD James, DB Phillips, SG Vincent… - The Journal of …, 2022 - Wiley Online Library
In patients with chronic obstructive pulmonary disease (COPD), exertional dyspnoea
generally arises when there is imbalance between ventilatory demand and capacity, but the …

Mechanisms of Exertional Dyspnea in Patients with Mild COPD and a Low Resting DLCO

MD James, DB Phillips, AF Elbehairy… - COPD: Journal of …, 2021 - Taylor & Francis
Patients with mild chronic obstructive pulmonary disease (COPD) and lower resting diffusing
capacity for carbon monoxide (DLCO) often report troublesome dyspnea during exercise …

Inspiratory constraints and ventilatory inefficiency are superior to breathing reserve in the assessment of exertional dyspnea in COPD

JA Neder, DC Berton, M Marillier… - COPD: Journal of …, 2019 - Taylor & Francis
Combining measurements of impaired lung mechanics (inspiratory constraints) with an
index of increased respiratory stimuli to metabolic demand (poor ventilatory efficiency) might …

Resting V′ E/V′ CO2 adds to inspiratory capacity to predict the burden of exertional dyspnoea in COPD

JA Neder, DC Berton, M Marillier… - European …, 2020 - Eur Respiratory Soc
Exertional dyspnoea is a cardinal symptom of patients with COPD [1]. Incremental
cardiopulmonary exercise testing (CPET), in particular, might provide useful mechanistic …

Exertional dyspnoea in patients with airway obstruction, with and without CO2 retention

SGM Cloosterman, ID Hofland, CP Van Schayck… - Thorax, 1998 - thorax.bmj.com
BACKGROUND Dyspnoea is a common and disabling symptom in patients with
cardiopulmonary disease. Unfortunately the mechanisms that produce dyspnoea are still …

Too rapid increase and too much breathlessness are distinct indices of exertional dyspnea in COPD

C Delclaux, B Chevalier-Bidaud, M Essalhi… - Respiratory physiology …, 2011 - Elsevier
To assess whether different indices of dyspnea can be obtained from cardiopulmonary
exercise test and whether these indices correlate with distinct physiological parameters in …

Chronic effort dyspnea explained by lung function tests and by HRCT and CRX radiographic patterns in COPD: a post-hoc analysis in 51 patients

C Giuntini, G Camiciottoli, NM Maluccio… - COPD: Journal of …, 2007 - Taylor & Francis
This paper is a post-hoc analysis of a previous study performed to investigate the
relationship between computerized tomography (CT) and lung function in 51 outpatients …