Motility is a universal property of newly generated neurons. How cell migration is
coordinately regulated with other aspects of neuron production is not well understood. Here …

The molecular mechanisms specifying the dendritic morphology of different neuronal
subtypes are poorly understood. Here we demonstrate that the bHLH transcription factor …

Little is known of the intracellular machinery that controls the motility of newborn neurons.
We have previously shown that the proneural protein Neurog2 promotes the migration of …

To study the role of basic helix–loop–helix (bHLH) transcription factors in gliogenesis, we
examined whether bHLH transcription factors were expressed in glial precursor cells and …

THE normal development of the vertebrate nervous system entails the death of 30–70% of
the neurons originally generated in most neuronal populations1. This naturally occurring cell …

Glial-cell-line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally
related, potent survival factors for sympathetic, sensory and central nervous system …

During peripheral nerve development, each segment of a myelinated axon is matched with a
single Schwann cell. Tight regulation of Schwann cell movement, proliferation and …

Repulsive guidance molecule (RGM) is an axon guidance protein that repels retinal axons
upon activation of the neogenin receptor. To understand the functions of RGM–neogenin …

Neurturin (NTN) is a recently identified homologue of glial-cell-line-derived neurotrophic
factor (GDNF). Both factors promote the survival of a variety of neurons,,,,, and GDNF is …

The proneural basic helix–loop–helix (bHLH) transcription factor neurogenin1 (Neurog1)
plays a pivotal role in neuronal differentiation during mammalian development. The …