[HTML][HTML] Molecular mechanisms of ROS-modulated cancer chemoresistance and therapeutic strategies

X Zhou, B An, Y Lin, Y Ni, X Zhao, X Liang - Biomedicine & …, 2023 - Elsevier
Drug resistance is the main obstacle to achieving a cure in many cancer patients. Reactive
oxygen species (ROS) are master regulators of cancer development that act through …

Modulating ROS to overcome multidrug resistance in cancer

Q Cui, JQ Wang, YG Assaraf, L Ren, P Gupta… - Drug Resistance …, 2018 - Elsevier
The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

[HTML][HTML] Modulation of redox homeostasis: A strategy to overcome cancer drug resistance

Y Li, X Zhang, Z Wang, B Li, H Zhu - Frontiers in Pharmacology, 2023 - frontiersin.org
Cancer treatment is hampered by resistance to conventional therapeutic strategies,
including chemotherapy, immunotherapy, and targeted therapy. Redox homeostasis …

[HTML][HTML] Implications of reactive oxygen species on cancer formation and its treatment

MA Shah, HA Rogoff - Seminars in Oncology, 2021 - Elsevier
Elevated levels of reactive oxygen species (ROS) are a hallmark of cancer. Although
increased ROS concentrations play important roles in cancer formation and progression …

The two faces of reactive oxygen species in cancer

CR Reczek, NS Chandel - Annual review of cancer biology, 2017 - annualreviews.org
Reactive oxygen species (ROS), now appreciated for their cellular signaling capabilities,
have a dual role in cancer. On the one hand, ROS can promote protumorigenic signaling …

Role of reactive oxygen species (ROS) in therapeutics and drug resistance in cancer and bacteria

AT Dharmaraja - Journal of Medicinal Chemistry, 2017 - ACS Publications
Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy

V Nogueira, N Hay - Clinical Cancer Research, 2013 - AACR
Reactive oxygen species (ROS) are important in regulating normal cellular processes, but
deregulated ROS contribute to the development of various human diseases, including …

ROS signalling in the biology of cancer

JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Genetic determinants of oxidative stress‐mediated sensitization of drug‐resistant cancer cells

AK Maiti - International journal of cancer, 2012 - Wiley Online Library
Drug resistance in cancer is an overwhelming problem, because drug‐resistant cancer cells
are harder to kill with the same drug. The mechanism of drug resistance differs for various …

Reactive oxygen species: the achilles' heel of cancer cells?

X Cui - Antioxidants & redox signaling, 2012 - liebertpub.com
Cancer development, progression, and metastasis are multistep processes. Accumulating
evidence suggests that reactive oxygen species (ROS) are critically involved in cancer cell …