The pattern of insulin release is crucial for regulation of glucose and lipid haemostasis.
Deficient insulin release causes hyperglycemia and diabetes, whereas excessive insulin …

Blood glucose concentration is controlled by a number of hormone and neurotransmitter
signals, either increasing or reducing glucose levels in the case of hypoglycemia or …

Blood glucose levels are sensed and controlled by the release of hormones from the islets of
Langerhans in the pancreas. The β-cell, the insulin-secreting cell in the islet, can detect …

Type 2 diabetes is characterized by high concentrations of glucose in the blood, which is
caused by decreased secretion of insulin from the pancreas and decreased insulin action …

Publisher Summary This chapter focuses on advances in therapeutic approaches to type 2
diabetes. In the US, about 10% of the diabetic population suffers from Type 1 diabetes, an …

Aims To understand better the control of insulin secretion by human β cells and to identify
similarities to and differences from rodent models. Methods Dynamic insulin secretion was …

Publisher Summary Several new mechanisms for the therapy of diabetes show considerable
promise for the expansion of the clinical options for the treatment of hyperglycemia. As new …

The objective of this study was to compare effects of RX-871024, a compound with
imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of …

Objective Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its
hyperglycemic effect helps to restore normal blood glucose. Insulin and somatostatin (SST) …

The sulphonylurea receptor (SUR) subunits of KATP channels are the targets for several
classes of therapeutic drugs. Sulphonylureas close KATP channels in pancreatic β-cells and …