Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and
metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha …

Abstract Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is the core active catalytic portion of
prolyl 4-hydroxylase, and has contributed to tumorigenesis in several cancers. In this study …

Background: Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) provides the majority of the
catalytic site of the active P4H enzyme. Emerging evidence has revealed that P4HA1 …

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy that is
associated with high levels of mortality. CRCs are often associated with an aberrant …

Background Increased collagen deposition provides physical and biochemical signals to
support tumor growth and invasion during breast cancer development. Therefore, inhibition …

Objective: Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen
synthesis, comprises two identical alpha subunits and two beta subunits. However, the …

Abstract Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) has been known to be associated
with a variety of human cancers. However, the role of P4HA3 on colon cancer growth and …

Glioblastoma (GBM) is a primary malignant tumor characterized by high infiltration and
angiogenesis in the brain parenchyma. Glioma stem cells (GSCs), a heterogeneous GBM …

Collagen prolyl hydroxylases (P3H) are required for proper collagen biosynthesis. One of
the family members P3H3 was downregulated in breast cancer and lymphoma due to DNA …

Background: Cervical cancer is one of the most common gynaecological malignancies.
Emerging studies have documented that prolyl-4-hydroxylase α subunit 2 (P4HA2) is …