Translational challenges in atrial fibrillation

J Heijman, JB Guichard, D Dobrev, S Nattel - Circulation research, 2018 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is associated
with substantial morbidity and mortality. Current treatment options for AF have significant …

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

S Nattel, PT Sager, J Hueser, J Heijman… - Cardiovascular …, 2021 - academic.oup.com
Atrial fibrillation (AF) is the most common sustained clinical arrhythmia, with a lifetime
incidence of up to 37%, and is a major contributor to population morbidity and mortality …

Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research …

P Kirchhof, J Bax, C Blomstrom-Lundquist… - European heart …, 2009 - academic.oup.com
Atrial fibrillation (AF) causes important mortality and morbidity on a population-level. So far,
we do not have the means to prevent AF or AF-related complications adequately. Therefore …

New insights into the mechanisms and management of atrial fibrillation

P Khairy, S Nattel - Cmaj, 2002 - Can Med Assoc
ATRIAL FIBRILLATION (AF) IS A COMMON CONTRIBUTOR to cardiovascular morbidity and
mortality. Two generally acceptable strategies exist for long-term AF management, with …

An update on atrial fibrillation in 2014: From pathophysiology to treatment

R Ferrari, M Bertini, C Blomstrom-Lundqvist… - International journal of …, 2016 - Elsevier
Atrial fibrillation (AF) is the most frequently encountered cardiac arrhythmia. The trigger for
initiation of AF is generally an enhanced vulnerability of pulmonary vein cardiomyocyte …

Novel approaches for pharmacological management of atrial fibrillation

JR Ehrlich, S Nattel - Drugs, 2009 - Springer
In the light of the progressively increasing prevalence of atrial fibrillation (AF), medical
awareness of the need to develop improved therapeutic approaches for the arrhythmia has …

The state of the art: atrial fibrillation epidemiology, prevention, and treatment

DP Morin, ML Bernard, C Madias, PA Rogers… - Mayo Clinic …, 2016 - Elsevier
As the most common sustained arrhythmia in adults, atrial fibrillation (AF) is an established
and growing epidemic. To provide optimal patient care, it is important for clinicians to be …

Controversies in atrial fibrillation

S Nattel, LH Opie - The Lancet, 2006 - thelancet.com
Atrial fibrillation is the most common sustained cardiac arrhythmia, and contributes greatly to
cardiovascular morbidity and mortality. Many aspects of the management of atrial fibrillation …

Atrial fibrillation pathophysiology: implications for management

Y Iwasaki, K Nishida, T Kato, S Nattel - Circulation, 2011 - Am Heart Assoc
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important
contributor to population morbidity and mortality. An arrhythmia that is particularly common …

Mechanisms of atrial fibrillation

RS Wijesurendra, B Casadei - Heart, 2019 - heart.bmj.com
Atrial fibrillation (AF) is the most common sustained arrhythmia, currently affecting over 33
million individuals worldwide, and its prevalence is expected to more than double over the …