Age represents the highest risk factor for death due to cardiovascular disease. Heart failure
(HF) is the most common cardiovascular disease in elder population and it is associated …

Heart failure (HF) is a major public health issue affecting more than 26 million people
worldwide. HF is the most common cardiovascular disease in elder population; and it is …

The molecular pathophysiology of heart failure, which is one of the leading causes of
mortality, is not yet fully understood. Heart failure can be regarded as a systemic syndrome …

Background: Chronic heart failure (CHF) impairs cognitive function, yet its effects on brain
structure and underlying mechanisms remain elusive. This study aims to explore the …

Background—How canonical Wnt/β-catenin signals in adult hearts, especially in different
diseased states, remains unclear. The proto-oncogene, c-Myc, is a Wnt target and an early …

Background: Beta-catenin has been implicated in cell-cell communication in a wide variety
of developmental and physiological processes. Defective Wnt signaling could result in …

Background Cognitive impairment is a serious comorbidity in heart failure patients, but
effective therapies are lacking. We investigated the mechanisms that alter hippocampal …

Heart failure (HF) is a major health burden worldwide, with approximately half of HF patients
having a comorbid cognitive impairment (CI). However, it is still unclear how CI develops in …

Heart failure (HF) is associated with multiple organ dysfunction and many comorbidities. Its
incidence is high among the elderly and is a major health burden worldwide. Cognitive …

Aim: The aim of the study was to identify genes whose expression is regulated by the β-
catenin, the indispensable component to the cWNT signaling, in the postmitotic myocytes …