Glaucoma causes loss of vision through degeneration of the retinal ganglion cell (RGC)
projection to the brain. The disease is characterized by sensitivity to intraocular pressure …

Diseases of the brain involve early axon dysfunction that often precedes outright
degeneration. Pruning of dendrites and their synapses represents a potential driver of …

Glaucoma is a common optic neuropathy with a complex etiology often linked to sensitivity to
intraocular pressure. Though the precise mechanisms that mediate or transduce this …

We tested the hypothesis that glaucoma disrupts electrophysiological conduction properties
and axon function in optic nerve as a function of intraocular pressure (IOP) levels and age in …

Glaucoma is a neurodegenerative disease of the visual system and leading cause of
blindness worldwide. The disease is associated with sensitivity to intraocular pressure (IOP) …

Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs)
associated with characteristic axon degeneration in the optic nerve. Clinically, our only …

Glaucoma challenges the survival of retinal ganglion cell axons in the optic nerve through
processes dependent on both aging and ocular pressure. Relevant stressors likely include …

Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …

Glaucoma is an age-related optic neuropathy involving sensitivity to ocular pressure. The
disease is now seen increasingly as one of the central nervous system, as powerful new …

Axonal degeneration is an active, highly controlled process that contributes to beneficial
processes, such as developmental pruning, but also to neurodegeneration. In glaucoma …