Osteosarcoma is a malignant primary tumor of bone, arising from transformed progenitor
cells with osteoblastic differentiation and osteoid production. While categorized as a rare …

Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Simple Summary Osteosarcomas are heterogeneous bone tumors with complex genetic and
chromosomic alterations. The numerous patients with metastatic osteosarcoma have a very …

Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current
treatment regime of surgery and intensive chemotherapy could cure about 60%–75 …

Patients who develop osteosarcoma in 2017 receive treatment that remains essentially
unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large …

Despite successful primary tumor treatment, the development of pulmonary metastasis
continues to be the most common cause of mortality in patients with osteosarcoma. A …

Background Osteosarcoma is a primary malignant tumor originating from mesenchymal
tissue, with a poor distant metastasis prognosis. The molecular mechanisms of …

Osteosarcoma (OS) is the most common primary bone malignancy and is frequently lethal
via metastasis to the lung. While surgical techniques and adjuvant chemotherapies have …

Bone is one of the most common sites of cancer metastasis in humans and is a significant
source of morbidity and mortality. Bone metastases are considered incurable and result in …

The two most common primary bone malignancies, osteosarcoma (OS), and Ewing sarcoma
(ES), are both aggressive, highly metastatic cancers that most often strike teens, though both …