Levodopa (L‐dopa) is the most widely used agent for the symptomatic relief of Parkinson's
disease. There is concern that chronic L‐dopa treatment may be detrimental, with some …

Levodopa (l-dopa), a close structural analogue of the protein amino acid l-tyrosine, can
substitute for l-tyrosine in protein synthesis and be mistakenly incorporated into newly …

Protein-bound 3, 4-dihydroxyphenylalanine (PB-DOPA) is a major product of hydroxyl
radical attack on tyrosine residues of proteins. Levels of PB-DOPA in cells and tissues have …

There is consensus that amelioration of the motor symptoms of Parkinson's disease is most
effective with l-DOPA (levodopa). However, this necessary therapeutic step is biased by an …

Despite the long clinical use of l-DOPA, the exact mechanism by which this drug alleviates
symptoms of Parkinson's disease is far from being fully understood. The present review …

Despite its being the most efficacious drug for symptom reversal in Parkinson's disease
(PD), there is concern that chronic levodopa (L-DOPA) treatment may be detrimental. In this …

Objectives: The intracellular (ic) content of dopamine and its metabolites was measured in
the peripheral blood lymphocytes (PBLs) of Parkinson's disease (PD) patients and healthy …

We used the technique of cerebral microdialysis to monitor the metabolism of exogenously
administered L-dopa and compared dopamine and dopamine metabolite formation in the …

The fundamental therapeutic actions of L-DOPA in Parkinson's disease are attributed to its
ability to be taken up into the brain where it is converted to dopamine (DA) by the enzyme …

Rats with unilateral 6-hydroxydopamine lesions of the midbrain tegmentum were treated
with 25 mg/kg l-DOPA methyl ester/2 mg/kg carbidopa. The effects of the l-DOPA treatment …