Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings
Genome-wide association studies (GWAS) have reported substantial genomic loci
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
significantly associated with clinical risk of bipolar disorder (BD), and studies combining …
Translational genomics and beyond in bipolar disorder
Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring
risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there …
risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there …
Genome‐wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications
M Ikeda, T Saito, K Kondo… - Psychiatry and clinical …, 2018 - Wiley Online Library
Recent advances in molecular genetics have enabled assessments of the associations
among genetic variants (eg, single‐nucleotide polymorphisms) and susceptibility for …
among genetic variants (eg, single‐nucleotide polymorphisms) and susceptibility for …
Identification of pathways for bipolar disorder: a meta-analysis
Importance Genome-wide investigations provide systematic information regarding the
neurobiology of psychiatric disorders. Objective To identify biological pathways that …
neurobiology of psychiatric disorders. Objective To identify biological pathways that …
The genetics of bipolar disorder
FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
Genetics of bipolar disorder: insights into its complex architecture and biology from common and rare variants
Bipolar disorder (BD) is a common mental disorder characterized by recurrent mood
episodes, which causes major socioeconomic burdens globally. Though its disease …
episodes, which causes major socioeconomic burdens globally. Though its disease …
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
DT Chen, X Jiang, N Akula, YY Shugart… - Molecular …, 2013 - nature.com
Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have
identified several genome-wide significant signals in European-ancestry samples, but so far …
identified several genome-wide significant signals in European-ancestry samples, but so far …
[HTML][HTML] An integrative genomic study implicates the postsynaptic density in the pathogenesis of bipolar disorder
N Akula, JR Wendland, KH Choi… - …, 2016 - nature.com
Genome-wide association studies (GWAS) have identified several common variants
associated with bipolar disorder (BD), but the biological meaning of these findings remains …
associated with bipolar disorder (BD), but the biological meaning of these findings remains …
Convergent functional genomics of genome‐wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms
H Le‐Niculescu, SD Patel, M Bhat… - American Journal of …, 2009 - Wiley Online Library
Given the mounting convergent evidence implicating many more genes in complex
disorders such as bipolar disorder than the small number identified unambiguously by the …
disorders such as bipolar disorder than the small number identified unambiguously by the …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …