Abstract 5HT 3 receptors (5HT3Rs) have long been identified as a potential target for
antidepressants. Several studies have reported that antagonism of 5HT3Rs produces …

Serotonin (5-HT) 3 receptors are the only ligand-gated ion channel of the 5-HT receptors
family. They are present both in the peripheral and central nervous system and are localized …

Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a
novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are …

Summary Serotonin (5‐hydroxytryptamine or 5‐HT) is an important neurotransmitter
regulating a wide range of physiological and pathological functions via activation of …

Clinical and preclinical studies report the implication of 5-hydroxytryptamine 4 receptors (5-
HT4Rs) in depression and anxiety. Here, we tested whether the absence of 5-HT4Rs …

Serotonin (5-HT) exerts its diverse physiological and pharmacological effects through the
activation of multiple receptor subtypes. One of the newest members of this family is the 5 …

The aim of this study was to further characterize pharmacological properties of two
phenylpiperazine derivatives: 1-{2-[2-(2, 6-dimethlphenoxy) ethoxy] ethyl}-4-(2 …

We report the discovery of novel 5-HT1A receptor agonists and describe the process that led
to the antidepressant candidate 9 (F 15599). 9 has nanomolar affinity for 5-HT1A binding …

The affinity of several antidepressant and antipsychotic drugs for the 5-HT7 receptor and its
CNS distribution suggest potential in the treatment of psychiatric diseases. However, there is …

BACKGROUND AND PURPOSE The antidepressant efficacy of selective 5‐HT reuptake
inhibitors (SSRI) and other 5‐HT‐enhancing drugs is compromised by a negative feedback …