Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a
wide variety of cells and play a major role in lipid signaling. NRs are key regulators of …

Mycobacterium tuberculosis–macrophage interactions are key to pathogenesis and
clearance of these bacteria. Although interactions between M. tuberculosis-associated lipids …

Mycobacterium tuberculosis instigates interactions with host factors to promote its survival
within the host inimical conditions. Among such factors, nuclear receptors (NRs) seem to be …

Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear transcription factor
belonging to the superfamily of ligand-activated nuclear receptors. It is activated by diverse …

Mycobacterium tuberculosis enhances its survival in macrophages by suppressing immune
responses in part through its complex cell wall structures. Peroxisome proliferator-activated …

Nuclear receptors (NRs) are ligand-activated transcription factors that are expressed in a
variety of cells, including macrophages. For decades, NRs have been therapeutic targets …

Macrophages, the major host cells harboring Mycobacterium tuberculosis (M. tb), are a
heterogeneous cell type depending on their tissue of origin and host they are derived from …

Retinoic acid (RA) is a fundamental vitamin A metabolite involved in regulating immune
responses through the nuclear RA receptor (RAR) and retinoid X receptor. While performing …

Peroxisome proliferator-activated receptor (PPAR) γ is a global transcriptional regulator
associated with anti-inflammatory actions. It is highly expressed in alveolar macrophages …

Alveolar macrophages (AMs) are the first cells to be infected during Mycobacterium
tuberculosis (M. tb.) infection. Thus, the AM response to infection is the first of many steps …