The effects of protein corona on in vivo fate of nanocarriers

Q Xiao, M Zoulikha, M Qiu, C Teng, C Lin, X Li… - Advanced Drug Delivery …, 2022 - Elsevier
With the emerging advances in utilizing nanocarriers for biomedical applications, a
molecular-level understanding of the in vivo fate of nanocarriers is necessary. After …

Protein corona on brain targeted nanocarriers: challenges and prospects

K Jiang, Y Yu, W Qiu, K Tian, Z Guo, J Qian… - Advanced Drug Delivery …, 2023 - Elsevier
Safe and efficient medical therapy for brain diseases is still an unmet clinical need due to
various barriers represented by the blood-brain barrier. Well-designed brain targeted …

The impact of protein corona on the biological behavior of targeting nanomedicines

M Farshbaf, H Valizadeh, Y Panahi, Y Fatahi… - International Journal of …, 2022 - Elsevier
For successful translation of targeting nanomedicines from bench to bedside, it is vital to
address their most common drawbacks namely rapid clearance and off-target accumulation …

[HTML][HTML] The Yin and Yang of the protein corona on the delivery journey of nanoparticles

YF Wang, Y Zhou, JB Sun, X Wang, Y Jia, K Ge, Y Yan… - Nano Research, 2023 - Springer
Nanoparticles-based drug delivery systems have attracted significant attention in biomedical
fields because they can deliver loaded cargoes to the target site in a controlled manner …

Controlling the stealth effect of nanocarriers through understanding the protein corona

S Schöttler, K Landfester… - Angewandte Chemie …, 2016 - Wiley Online Library
The past decade has seen a significant increase in interest in the use of polymeric
nanocarriers in medical applications. In particular, when used as drug vectors in targeted …

[HTML][HTML] Research progress and application opportunities of nanoparticle–protein corona complexes

W Huang, G Xiao, Y Zhang, W Min - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Nanoparticles (NPs) can be used to design for nanomedicines with different chemical
surface properties owing to their size advantages and the capacity of specific delivery to …

Unveiling the pitfalls of the protein corona of polymeric drug nanocarriers

G Berrecoso, J Crecente-Campo, MJ Alonso - Drug delivery and …, 2020 - Springer
The protein corona is a natural protein layer spontaneously formed around nanomaterials
when exposed to biological media. This layer can alter the nanosystems' biological …

[HTML][HTML] Impact of protein corona on the biological identity of nanomedicine: understanding the fate of nanomaterials in the biological milieu

MH Akhter, H Khalilullah, M Gupta, MA Alfaleh… - Biomedicines, 2021 - mdpi.com
Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a
number of protein molecules resulting in the formation of an NP–protein complex called …

Ligand size and conformation affect the behavior of nanoparticles coated with in vitro and in vivo protein corona

H Zhang, T Wu, W Yu, S Ruan, Q He… - ACS applied materials & …, 2018 - ACS Publications
Protein corona is immediately established on the surface of nanoparticles upon their
introduction into biological milieu. Several studies have shown that the targeting efficiency of …

The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system

W Xiao, H Gao - International Journal of Pharmaceutics, 2018 - Elsevier
Once introduced into physiological environment, nanoparticles (NPs) are immediately
coated with proteins, resulting in formation of what is known as protein corona. The …