[HTML][HTML] Targeting mitochondrial metabolic dysfunction in pulmonary hypertension: toward new therapeutic approaches?
M Riou, I Enache, F Sauer, AL Charles… - International journal of …, 2023 - mdpi.com
Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary
vascular remodeling leading to right heart failure and death. To date, despite the three …
vascular remodeling leading to right heart failure and death. To date, despite the three …
[HTML][HTML] Mitochondrial metabolism, redox, and calcium homeostasis in pulmonary arterial hypertension
S Liang, M Yegambaram, T Wang, J Wang, SM Black… - Biomedicines, 2022 - mdpi.com
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated
pulmonary arterial pressure due to increased pulmonary vascular resistance, secondary to …
pulmonary arterial pressure due to increased pulmonary vascular resistance, secondary to …
[HTML][HTML] Acquired disorders of mitochondrial metabolism and dynamics in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is an orphan disease of the cardiopulmonary unit
that reflects an obstructive pulmonary vasculopathy and presents with hypertrophy …
that reflects an obstructive pulmonary vasculopathy and presents with hypertrophy …
[HTML][HTML] The metabolic basis of pulmonary arterial hypertension
G Sutendra, ED Michelakis - Cell metabolism, 2014 - cell.com
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of the lungs
resulting in heart failure and premature death. Although, until recently, it was thought that …
resulting in heart failure and premature death. Although, until recently, it was thought that …
The metabolic theory of pulmonary arterial hypertension
R Paulin, ED Michelakis - Circulation research, 2014 - Am Heart Assoc
Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …
Metabolism in pulmonary hypertension
W Xu, AJ Janocha, SC Erzurum - Annual review of physiology, 2021 - annualreviews.org
Pulmonary arterial hypertension (PAH) is characterized by impaired regulation of pulmonary
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
hemodynamics and vascular growth. Alterations of metabolism and bioenergetics are …
Mitochondrial and metabolic drivers of pulmonary vascular endothelial dysfunction in pulmonary hypertension
Q Yu, SY Chan - Pulmonary vasculature redox signaling in health and …, 2017 - Springer
Pulmonary hypertension (PH) is a deadly and increasingly prevalent vascular disease
characterized by excessive pulmonary vascular remodeling and right ventricular dysfunction …
characterized by excessive pulmonary vascular remodeling and right ventricular dysfunction …
Mitochondrial dysfunction: metabolic drivers of pulmonary hypertension
HB Suliman, E Nozik-Grayck - Antioxidants & redox signaling, 2019 - liebertpub.com
Significance: Pulmonary hypertension (PH) is a progressive disease characterized by
pulmonary vascular remodeling and lung vasculopathy. The disease displays progressive …
pulmonary vascular remodeling and lung vasculopathy. The disease displays progressive …
Oxidative and nitrosative signalling in pulmonary arterial hypertension—Implications for development of novel therapies
Pulmonary arterial hypertension (PAH) is a syndrome characterised by an increase in
pulmonary vascular resistance. This results in elevated resting pulmonary artery pressure …
pulmonary vascular resistance. This results in elevated resting pulmonary artery pressure …
[HTML][HTML] Metabolism, mitochondrial dysfunction, and redox homeostasis in pulmonary hypertension
D Colon Hidalgo, H Elajaili, H Suliman, MP George… - Antioxidants, 2022 - mdpi.com
Pulmonary hypertension (PH) represents a group of disorders characterized by elevated
mean pulmonary artery (PA) pressure, progressive right ventricular failure, and often death …
mean pulmonary artery (PA) pressure, progressive right ventricular failure, and often death …