Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis
Background Increased circulating plasma urate concentration is associated with an
increased risk of coronary heart disease, but the extent of any causative effect of urate on …
increased risk of coronary heart disease, but the extent of any causative effect of urate on …
Causal assessment of serum urate levels in cardiometabolic diseases through a Mendelian randomization study
Background: Although epidemiological studies have reported positive associations between
circulating urate levels and cardiometabolic diseases, causality remains uncertain …
circulating urate levels and cardiometabolic diseases, causality remains uncertain …
Urate, blood pressure, and cardiovascular disease: evidence from mendelian randomization and meta-analysis of clinical trials
Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …
Uric acid and cardiovascular risk: What genes can say
A Kei, F Koutsouka, A Makri… - International Journal of …, 2018 - Wiley Online Library
Background Although the relationship of elevated serum uric acid levels and cardiovascular
disease has been established in a great number of studies, the causal relevance of this …
disease has been established in a great number of studies, the causal relevance of this …
Serum uric acid and risk of cardiovascular mortality: a systematic review and dose-response meta-analysis of cohort studies of over a million participants
F Rahimi-Sakak, M Maroofi, J Rahmani… - BMC Cardiovascular …, 2019 - Springer
Background Cardiovascular disease (CVD) is the leading cause of death worldwide. Some
studies have suggested anassociation between serum uric acid levels and cardiovascular …
studies have suggested anassociation between serum uric acid levels and cardiovascular …
[HTML][HTML] Serum uric acid levels and cardiovascular disease: the Gordian knot
E Martínez-Quintana, A Tugores… - Journal of thoracic …, 2016 - ncbi.nlm.nih.gov
Hyperuricemia is defined as serum uric acid level of more than 7 mg/dL and blood levels of
uric acid are causally associated with gout, as implicated by evidence from randomized …
uric acid are causally associated with gout, as implicated by evidence from randomized …
Uric acid and cardiovascular events: a Mendelian randomization study
ME Kleber, G Delgado, TB Grammer… - Journal of the …, 2015 - journals.lww.com
Obesity and diets rich in uric acid–raising components appear to account for the increased
prevalence of hyperuricemia in Westernized populations. Prevalence rates of hypertension …
prevalence of hyperuricemia in Westernized populations. Prevalence rates of hypertension …
Genetically determined uric acid and the risk of cardiovascular and neurovascular diseases: a Mendelian randomization study of outcomes investigated in randomized …
Background Higher serum uric acid levels are associated with cardiovascular and
neurovascular disease, but whether these relationships are causal is not known. We applied …
neurovascular disease, but whether these relationships are causal is not known. We applied …
Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels
H Rasheed, K Hughes, TJ Flynn… - Circulation …, 2014 - Am Heart Assoc
Background—Triglycerides and their lipoprotein transport molecules are risk factors for heart
disease. Observational studies have associated elevated levels of serum urate (SU) with …
disease. Observational studies have associated elevated levels of serum urate (SU) with …
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study
Background The role of urate in cardiovascular diseases (CVDs) has been extensively
investigated in observational studies; however, the extent of any causal effect remains …
investigated in observational studies; however, the extent of any causal effect remains …
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