Background Increased circulating plasma urate concentration is associated with an
increased risk of coronary heart disease, but the extent of any causative effect of urate on …

Background: Although epidemiological studies have reported positive associations between
circulating urate levels and cardiometabolic diseases, causality remains uncertain …

Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …

Background Although the relationship of elevated serum uric acid levels and cardiovascular
disease has been established in a great number of studies, the causal relevance of this …

Background Cardiovascular disease (CVD) is the leading cause of death worldwide. Some
studies have suggested anassociation between serum uric acid levels and cardiovascular …

Hyperuricemia is defined as serum uric acid level of more than 7 mg/dL and blood levels of
uric acid are causally associated with gout, as implicated by evidence from randomized …

Obesity and diets rich in uric acid–raising components appear to account for the increased
prevalence of hyperuricemia in Westernized populations. Prevalence rates of hypertension …

Background Higher serum uric acid levels are associated with cardiovascular and
neurovascular disease, but whether these relationships are causal is not known. We applied …

Background—Triglycerides and their lipoprotein transport molecules are risk factors for heart
disease. Observational studies have associated elevated levels of serum urate (SU) with …

Background The role of urate in cardiovascular diseases (CVDs) has been extensively
investigated in observational studies; however, the extent of any causal effect remains …