Different physiological and pathological conditions can perturb protein folding in the
endoplasmic reticulum, leading to a condition known as ER stress. ER stress activates a …

Cancer cells encounter numerous stresses that pose a threat to their survival. Tumor
microenviroment stresses that perturb protein homeostasis can produce endoplasmic …

The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating
tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high …

The endoplasmic reticulum (ER) acts as a moving organelle with many important cellular
functions. As the ER lacks sufficient nutrients under pathological conditions leading to …

The unfolded protein response (UPR) is a stress response activated by the accumulation of
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …

The endoplasmic reticulum (ER) is involved in the quality control of secreted protein via
promoting the correct folding of nascent protein and mediating the degradation of unfolded …

Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of
endogenous and exogenous insults, prompts a cellular stress condition known as ER stress …

The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells, responsible for
protein synthesis, folding, sorting, and transportation. ER stress is initiated when the …

Given the inherent resistance to apoptosis that characterizes cancer, the targeting of
alternative pathways is an attractive strategy to improve anti-tumor therapy. Endoplasmic …

A variety of cell intrinsic or extrinsic stresses evoke perturbations in the folding environment
of the endoplasmic reticulum (ER), collectively known as ER stress. Adaptation to stress and …