Linking ER stress to autophagy: potential implications for cancer therapy
Different physiological and pathological conditions can perturb protein folding in the
endoplasmic reticulum, leading to a condition known as ER stress. ER stress activates a …
endoplasmic reticulum, leading to a condition known as ER stress. ER stress activates a …
Regulation of autophagy by canonical and non-canonical ER stress responses
Cancer cells encounter numerous stresses that pose a threat to their survival. Tumor
microenviroment stresses that perturb protein homeostasis can produce endoplasmic …
microenviroment stresses that perturb protein homeostasis can produce endoplasmic …
Unfolded protein response to autophagy as a promising druggable target for anticancer therapy
The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating
tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high …
tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high …
[HTML][HTML] Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response
Y Lin, M Jiang, W Chen, T Zhao, Y Wei - Biomedicine & Pharmacotherapy, 2019 - Elsevier
The endoplasmic reticulum (ER) acts as a moving organelle with many important cellular
functions. As the ER lacks sufficient nutrients under pathological conditions leading to …
functions. As the ER lacks sufficient nutrients under pathological conditions leading to …
[HTML][HTML] Endoplasmic reticulum stress and unfolded protein response in breast cancer: the balance between apoptosis and autophagy and its role in drug resistance
L Sisinni, M Pietrafesa, S Lepore, F Maddalena… - International journal of …, 2019 - mdpi.com
The unfolded protein response (UPR) is a stress response activated by the accumulation of
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …
[HTML][HTML] Interplay between unfolded protein response and autophagy promotes tumor drug resistance
MM Yan, JD Ni, D Song, M Ding… - Oncology …, 2015 - spandidos-publications.com
The endoplasmic reticulum (ER) is involved in the quality control of secreted protein via
promoting the correct folding of nascent protein and mediating the degradation of unfolded …
promoting the correct folding of nascent protein and mediating the degradation of unfolded …
Targeting ER stress induced apoptosis and inflammation in cancer
T Verfaillie, AD Garg, P Agostinis - Cancer letters, 2013 - Elsevier
Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of
endogenous and exogenous insults, prompts a cellular stress condition known as ER stress …
endogenous and exogenous insults, prompts a cellular stress condition known as ER stress …
The unfolded protein response as a target for anticancer therapeutics
M Wang, ME Law, RK Castellano, BK Law - Critical reviews in oncology …, 2018 - Elsevier
The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells, responsible for
protein synthesis, folding, sorting, and transportation. ER stress is initiated when the …
protein synthesis, folding, sorting, and transportation. ER stress is initiated when the …
Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: implications for future therapeutic approaches
SM Schleicher, L Moretti, V Varki, B Lu - Drug resistance updates, 2010 - Elsevier
Given the inherent resistance to apoptosis that characterizes cancer, the targeting of
alternative pathways is an attractive strategy to improve anti-tumor therapy. Endoplasmic …
alternative pathways is an attractive strategy to improve anti-tumor therapy. Endoplasmic …
Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy
F Tameire, II Verginadis, C Koumenis - Seminars in cancer biology, 2015 - Elsevier
A variety of cell intrinsic or extrinsic stresses evoke perturbations in the folding environment
of the endoplasmic reticulum (ER), collectively known as ER stress. Adaptation to stress and …
of the endoplasmic reticulum (ER), collectively known as ER stress. Adaptation to stress and …