The release of transmitter from noradrenergic nerve endings per unit time depends on the
rate of impulse flow on the one hand and the release per impulse on the other hand …

During norepinephrine release elecited by the arrival of nerve impulses, the
neurotransmitter interacts with specific receptors (alpha1-, beta1-, beta2-adrenoceptors) …

Reviews studies of possible mechanisms involved in regulating the amount of the
neurotransmitter norepinephrine, released upon arrival of impulses at adrenergic nerve …

It is now well established that adrenergic neurotransmission is a complex phenomenon that
involves several biophysical and biochemical interactions. In order for the transmission …

At least three groups of receptors are essential in chemical neurotransmission (Fig. 1).
Firstly, receptors on soma and dendrites of the innervating neurone determine the frequency …

It is with deep gratitude that I receive the honour of having been selected by the Trustees of
the Gaddum Memorial Fund to deliver the Sixth Gaddum Memorial Lecture. Among many …

The influence of infusions of unlabelled (−)-noradrenaline on the release of previously
stored (±)-14 C-noradrenaline was investigated in the isolated perfused rabbit heart. 1. The …

One of the most widely used invitro methods to study pFesynaptic modulation of transmitter
release from noradrenergic neurorts is superfusion and electrical field stimulation of tissues …

Abstract 1 The effects of isoprenaline, propranolol and phentolamine, were studied on
tritiated noradrenaline overflow elicited by postganglionic nerve stimulation in guinea-pig …

The activation of presynaptic receptors produces either inhibition [eg a,-adrenergic,
muscarinic and y-aminobutyrate (GABA) agonists, opioids, purines and prostaglandins] or …