Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia
SB Foley, ZL Hildenbrand, AA Soyombo, JA Magee… - Cell reports, 2013 - cell.com
Chronic myeloid leukemia (CML) and some acute lymphoblastic leukemias are
characterized by the t (9; 22) chromosome, which encodes the BCR/ABL oncogene. Multiple …
characterized by the t (9; 22) chromosome, which encodes the BCR/ABL oncogene. Multiple …
Re-evaluating the role of BCR/ABL in chronic myelogenous leukemia
TS Ross, VE Mgbemena - Molecular & cellular oncology, 2014 - Taylor & Francis
Chronic myelogenous leukemia (CML) requires the BCR/ABL tyrosine kinase for disease
onset and maintenance. As a result, CML can be successfully treated with tyrosine kinase …
onset and maintenance. As a result, CML can be successfully treated with tyrosine kinase …
Leukemogenesis of b2a2-type p210 BCR/ABL in a bone marrow transplantation mouse model using a lentiviral vector
N Uchida, H Hanawa, K Dan, K Inokuchi… - Journal of Nippon …, 2009 - jstage.jst.go.jp
The BCR/ABL fusion oncogene found in Philadelphia-positive leukemia exists in three
principle forms: p190, p210 and p230. P210 BCR/ABL is commonly found in patients with …
principle forms: p190, p210 and p230. P210 BCR/ABL is commonly found in patients with …
Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate
T Era, ON Witte - Proceedings of the National Academy of …, 2000 - National Acad Sciences
P210 Bcr-Abl is an activated tyrosine kinase oncogene encoded by the Philadelphia
chromosome associated with human chronic myelogenous leukemia (CML). The disease …
chromosome associated with human chronic myelogenous leukemia (CML). The disease …
Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias
Chronic myelogenous leukemia is a myeloproliferative disorder (MPD) that, over time,
progresses to acute leukemia. Both processes are closely associated with the t (9; 22) …
progresses to acute leukemia. Both processes are closely associated with the t (9; 22) …
Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel …
X Zhang, R Ren - Blood, The Journal of the American Society …, 1998 - ashpublications.org
The bcr-abl oncogene plays a critical role in causing chronic myelogenous leukemia (CML).
Effective laboratory animal models of CML are needed to study the molecular mechanisms …
Effective laboratory animal models of CML are needed to study the molecular mechanisms …
A BCR-ABLp190 Fusion Gene Made by Homologous Recombination Causes B-Cell Acute Lymphoblastic Leukemias in Chimeric Mice With Independence of the …
BCR-ABLp190 oncogene is the result of a reciprocal translocation between chromosomes 9
and 22 and is associated with B-cell acute lymphoblastic leukemia (B-ALL) in humans …
and 22 and is associated with B-cell acute lymphoblastic leukemia (B-ALL) in humans …
BCR/ABL and leukemia
A Butturini, RB Arlinghaus, RP Gale - Leukemia research, 1996 - Elsevier
This review focuses on the role of the chimeric BCR/ABL gene in leukemia development.
First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We …
First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We …
Bcr/Abl associated leukemogenesis in bcr null mutant mice
JW Voncken, V Kaartinen, J Groffen, N Heisterkamp - Oncogene, 1998 - nature.com
The BCR gene contributes to Philadelphia-positive leukemogenesis via a number of
discrete mechanisms, one of which may be through interaction of its normal gene product …
discrete mechanisms, one of which may be through interaction of its normal gene product …
Bcr: a negative regulator of the Bcr-Abl oncoprotein
Y Wu, G Ma, D Lu, F Lin, HJ Xu, J Liu, RB Arlinghaus - Oncogene, 1999 - nature.com
Chronic myelogenous leukemia is typically characterized by the presence of the
Philadelphia chromosome (Ph) in which 5′ portions of the BCR gene are fused to a large …
Philadelphia chromosome (Ph) in which 5′ portions of the BCR gene are fused to a large …