Alternative splicing and polyadenylation represent two major steps in pre‐mRNA‐
processing, which ensure proper gene expression and diversification of human …

Alternative splicing allows cells to expand the encoding potential of their genomes. In this
elegant mechanism, a single gene can yield protein isoforms with even antagonistic …

Phosphorylation has been generally thought to activate the SR family of splicing factors for
efficient splice-site recognition, but this idea is incompatible with an early observation that …

SR Protein Kinases (SRPKs), discovered approximately 30 years ago, are widely known as
splice factor kinases due to their decisive involvement in the regulation of various steps of …

Aberrant patterns of pre-mRNA processing are typical of human malignancies, yet the
mechanisms responsible for these changes remain undefined. We have recently shown …

Alternative pre-mRNA splicing in higher eukaryotes enhances transcriptome complexity and
proteome diversity. Its regulation is mediated by a complex RNA-protein network that is …

Accumulating evidence has demonstrated the importance of alternative splicing in various
physiological processes, including the development of different diseases. CDC-like kinases …

Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis of
several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role …

Pre-mRNA splicing is regulated by developmental and environmental cues, but little is
known about how specific signals are transduced in mammalian cells to regulate this critical …

Reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian
cells. Two kinases, SR protein-specific kinase (SRPK1) and Clk/Sty, have been shown to …