In general populations, age-dependent renal impairment contributes to the progression of
renal dysfunction. It has not been known which molecules are involved in age-dependent …

Background Age-dependent renal impairment contributes to renal dysfunction in both the
general population and young and middle-aged patients with renal diseases. Pathological …

MicroRNAs (miRNAs) are small, noncoding RNAs consisting of 21-25 bases. They are not
translated into proteins but rather work to impede the functioning of their target messenger …

Abstract Background Long noncoding RNAs (lncRNAs) are involved in physiological and
pathological processes. However, no studies have been conducted on the relationship …

Renal aging is a natural process that can lead to structural changes and functional decline
in the kidneys. These age-related changes are considered irreversible physiological …

Little is known about the molecular changes that take place in the kidney during the aging
process. In order to better understand these changes, we measured mRNA and protein …

MicroRNAs (miRNAs) play important roles in the regulation of cellular function and fate via
post-transcriptional regulation of gene expression. Although several miRNAs are associated …

Background Growing evidence suggests that epigenetic mechanisms of gene regulation
may play a role in susceptibilities to specific toxicities and adverse drug reactions. MiRNAs …

Transcriptional analysis of the molecular basis of human kidney aging using cDNA
microarray profiling. Background The molecular basis of renal aging is not completely …

In this study, we found 985 genes that change expression in the cortex and the medulla of
the kidney with age. Some of the genes whose transcripts increase in abundance with age …