During puberty, when young people are completing their education, transitioning into
employment, and forming longer-term intimate relationships, a shift in emotional regulation …

Substance use in young people (aged 10–24 years) might disrupt key periods of transition
that occur as the adolescent brain undergoes cognitive and emotional development, and …

We did a systematic review of reviews with evidence on the effectiveness of prevention,
early intervention, harm reduction, and treatment of problem use in young people for …

Adolescence is a time of change: changes to hormones and the body, changes in the social
environment, and changes to the brain and the mind. Although most young people develop …

The burden of mental, neurological, and substance use (MNS) disorders increased by 41%
between 1990 and 2010 and now accounts for one in every 10 lost years of health globally …

Background Debate continues about the consequences of adolescent cannabis use.
Existing data are limited in statistical power to examine rarer outcomes and less common …

The citizens of four US states—Alaska, Colorado, Oregon, and Washington—have voted to
legalise the sale of cannabis to adults for recreational purposes, and more states look likely …

Background The role of alcohol use in the development of depression is unclear. We aimed
to investigate whether alcohol dependence, but not high frequency or quantity of …

The Outcome Document of the 2016 United Nations General Assembly Special Session on
drugs (UNGASS 2016), unanimously approved by the 193 Member States, has recognized …

Adolescence is a life phase in which the opportunities for health are great and future
patterns of adult health are established. Health in adolescence is the result of interactions …