The interferon (IFN) induced anti-viral response is amongst the earliest and most potent of
the innate responses to fight viral infection. The induction of the Janus kinase/signal …

Abstract Interferon-alpha (IFN-α) is a potent anti-viral cytokine, critical to the host immune
response against viruses. IFN-α is first produced upon viral detection by pathogen …

Interferons (IFNs), which were discovered a half century ago, are a group of secreted
proteins that play key roles in innate immunity against viral infection. The major signaling …

The type I and II interferons (IFNs) are potent stimulators of antigen processing and
presentation and are essential in antiviral immunity. IFNs upregulate the transcription of …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

Type I interferons (IFNs) play a crucial role in the innate immune avant-garde against viral
infections. Virtually all viruses have developed means to counteract the induction, signaling …

Interferons (IFNs) elicit multifaceted effects in host innate defence. Accumulating evidence
revealed that not only the first identified Jak‐Stat pathway but also other newly found …

Viruses need to multiply extensively in the infected host in order to ensure transmission to
new hosts and survival as a population. This is a formidable task, given the powerful innate …

For several decades there has been accumulating evidence implicating type I interferons
(IFNs) as key elements of the immune response. Therapeutic approaches incorporating …

Viruses have learned to multiply in the face of a powerful innate and adaptive immune
response of the host. They have evolved multiple strategies to evade the interferon (IFN) …