Administration of the microtubule inhibitor docetaxel is a common treatment for metastatic
castration-resistant prostate cancer (mCRPC) and results in prolonged patient overall …

Bladder cancer is one of the most common urogenital malignancies. At the non-invasive
stage, bladder cancer can be completely resected transurethrally. However, 70% of patients …

Standard therapy for nonorgan confined prostate cancer aims to block the production or
action of androgens. Although initially successful, antiandrogen therapy eventually fails and …

e16534 Background: Growth and survival of prostate cancer cells are initially dependent
upon androgens, and androgen deprivation therapy (ADT) is used to control tumor growth …

Inhibitors of histone deacetylases have been approved for clinical application in cancer
treatment. On the other hand, histone acetyltransferase (HAT) inhibitors have been less …

Although prostate cancer (PCa) is the most frequently diagnosed cancer in males, little is
known about the mechanisms involved in its progression. Recent in vitro studies suggest …

Prostate cancer is one of the most common malignant diseases in men, and it contributes
significantly to the increased mortality rate in men worldwide. This study aimed to review the …

An important strategy for improving advanced PCa treatment is targeted therapies combined
with chemotherapy. PC-1, a prostate Leucine Zipper gene (PrLZ), is specifically expressed …

Reduced SIRT2 deacetylation and increased p300 acetylation activity leads to a concerted
mechanism of hyperacetylation at specific histone lysine sites (H3K9, H3K14, and H3K18) in …

Prostate cancer is among most malignant tumors around the world and this urological tumor
can be developed as result of genomic mutations and their accumulation during progression …