Serotonin has been implicated in the control of satiety for almost four decades. Historically,
the insight that the appetite suppressant effect of fenfluramine is linked to serotonin has …

It is approximately 20 years since the serotonin (5-hydroxytryptamine; 5-HT) hypothesis of
appetite control was formally stated. In that time, evidence has accumulated to confirm the …

Over 35 years of research suggests that endogenous hypothalamic serotonin (5-
hydroxytryptamine) plays an important part in within-meal satiation and post-meal satiety …

Serotonin (5-HT) has been implicated in the control of eating behavior and body weight.
Stimulants of this monoamine reduce food intake and weight gain and increase energy …

It was first established in the 1970s that the brain serotonin (5-HT) system was involved in
the control of eating. Subsequent progress in the molecular pharmacology of 5-HT …

The role of serotonin (5-HT) in appetite control is well recognised. 5-HT drugs reduce food
intake in rodents in a manner consistent with an enhancement of satiety. In humans, they …

Studies in which serotonergic drugs were administered either systemically or directly into
central sites have implicated 5-HT in the inhibitory control of feeding in mammals. In animal …

This paper reviews the evidence of serotoninergic mechanisms in human feeding by
considering the effects of 5-HT agonists, precursors and receptor antagonists on hunger …

The attenuation of food intake as induced by an increase in serotonergic (5‐
hydroxytryptamine, 5‐HT) efficacy has been a target of antiobesity pharmacotherapies …

Recent pharmacological studies have more precisely characterised the nature of the
inhibitory effect of brain serotonin (5-hydroxytryptamine) on feeding behaviour. Thus, the …