Metabolic landscape and sensitivity to apoptosis induction play a crucial role in acute
myeloid leukemia (AML) resistance. Therefore, we investigated the effect of metformin, a …

Abstract Treatment of acute myeloid leukemia (AML) is still a challenge because of common
relapses or resistance to treatment. Therefore, the development of new therapeutic …

Simple Summary Acute myeloid leukemia is a group of metabolic heterogeneous cancers, of
which the long-term overall survival is still poor, especially in elderly patients. Targeting …

Previous reports demonstrate that metformin, an anti-diabetic drug, can decrease the risk of
cancer and inhibit cancer cell growth. However, its mechanism in cancer cells is still …

Acute myeloid leukaemia (AML) comprises a heterogeneous group of hematologic
neoplasms characterized by diverse combinations of genetic, phenotypic and clinical …

Metformin exerts direct anti-tumor effects by activating AMP-activated protein kinase (AMPK),
a major sensor of cellular metabolism in cancer cells. This, in turn, inhibits pro-survival …

Aims Chemo-resistance still was the main obstacle for AML patients, more effective and less
toxic forms of therapies were desperately needed. Metformin, a classic hypoglycemic drug …

Acute myeloid leukemia (AML) is an aggressive blood cancer resulting in accumulation of
immature, dysfunctional blood cells in the bone marrow. Changes in cell metabolism are …

Introduction Despite the ability of cancer cells to survive glucose deprivation, most studies
on anti-cancer effect of metformin explored its impact on glucose metabolism. No study ever …

Acute myeloid leukemia (AML) cells frequently adjust to increased energy/substrate demand
under stress conditions in the bone marrow microenvironment. Recent studies indicate that …