Fundamental features of 3D genome organization are established de novo in the early
embryo, including clustering of pericentromeric regions, the folding of chromosome arms …

In mammals, chromatin organization undergoes drastic reprogramming after fertilization.
However, the three-dimensional structure of chromatin and its reprogramming in …

Metazoan genomes are spatially organized at multiple scales, from packaging of DNA
around individual nucleosomes to segregation of whole chromosomes into distinct …

The establishment of cell types during development requires precise interactions between
genes and distal regulatory sequences. We have a limited understanding of how these …

Eukaryotic genomes are folded into three-dimensional structures, such as self-associating
topological domains, the borders of which are enriched in cohesin and CCCTC-binding …

Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …

Eukaryotic chromosomes are organized in multiple scales, from nucleosomes to
chromosome territories. Recently, genome-wide methods identified an intermediate level of …

The spatial organization of the genome is intimately linked to its biological function, yet our
understanding of higher order genomic structure is coarse, fragmented and incomplete. In …

CELL patterning in the body segments of the Drosophila embryo requires activity of the
segment polarity genes, a molecularly heterogeneous group defined by a generic mutant …

Paternal and maternal epigenomes undergo marked changes after fertilization. Recent
epigenomic studies have revealed the unusual chromatin landscapes that are present in …