Background We now know that depression is associated with a chronic, low-grade
inflammatory response and activation of cell-mediated immunity, as well as activation of the …

Depression and inflammation fuel one another. Inflammation plays a key role in
depression's pathogenesis for a subset of depressed individuals; depression also primes …

While it is unlikely that Major Depressive Disorder (MDD) is a primary and pure
'inflammatory'disease, evidence is accumulating to show that depression and inflammation …

Accumulating evidence supports an association between depression and inflammatory
processes, a connection that seems to be bidirectional. Clinical trials have indicated …

This chapter explores the evidence supporting inflammation-associated depression. Data to
date suggest a bidirectional relationship between inflammation and depression wherein one …

Like all psychiatric conditions, depression is a complex phenomenon that is unlikely to yield
to simple monolithic explanatory paradigms. Nonetheless, increasing evidence suggests …

Accumulating data have led to a re-conceptualization of depression that emphasizes the
role of immune-inflammatory processes, coupled to oxidative and nitrosative stress (O&NS) …

That inflammation plays an important role in depression has garnered considerable
attention. Nevertheless, increasing data suggest that inflammation's effects on the brain may …

Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Consistent evidence links major depression and its affective components to negative health
outcomes. Although the pathways of these effects are likely complex and multifactorial …