Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …

Traumatic brain injury (TBI) is associated with an increased risk of cognitive, psychiatric, and
neurodegenerative complications that may develop after injury. Increased microglial …

Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and
neurodegenerative pathologies, which develop and persist years after injury …

Microglia mediate chronic neuroinflammation following central nervous system (CNS)
disease or injury, and in doing so, damage the local brain environment by impairing …

With severe injury or disease, microglia become chronically activated and damage the local
brain environment, likely contributing to cognitive decline. We previously discovered that …

Microglia undergo dynamic structural and transcriptional changes during the immune
response to traumatic brain injury (TBI). For example, TBI causes microglia to form rod …

Brain ischemia elicits microglial activation and microglia survival depend on signaling
through colony-stimulating factor 1 receptor (CSF1R). Although depletion of microglia has …

Traumatic brain injury (TBI) induces secondary injury mechanisms, including cell-cycle
activation (CCA), which lead to neuronal cell death, microglial activation, and neurologic …

DNA damage and type I interferons (IFNs) contribute to inflammatory responses after
traumatic brain injury (TBI). TBI-induced activation of microglia and peripherally-derived …

Aged microglia display augmented inflammatory activity after neural injury. Although aging
is a risk factor for poor outcome after brain insults, the precise impact of aging-related …