Radioresistance is a major challenge in prostate cancer (CaP) radiotherapy (RT). In this
study, we investigated the role and association of epithelial–mesenchymal transition (EMT) …

Abstract The PI3K/Akt/mTOR pathway has a central role in cancer metastasis and
radiotherapy. To develop effective therapeutics to improve radiosensitivity, understanding …

Radiation therapy (RT) continues to be one of the most popular treatment options for
localized prostate cancer (CaP). Local CaP recurrence after RT is a pattern of treatment …

Radiation therapy plays an important role in the management of prostate carcinoma.
However, the problem of radioresistance and molecular mechanisms by which prostate …

Abstract The phosphatidylinositol-3-kinase/Akt and the mammalian target of rapamycin
(PI3K/Akt/mTOR) pathway is one of the most frequently activated signaling pathways in …

Fractionated ionizing radiation combined with surgery or hormone therapy represents the
first-choice treatment for medium to high-risk localized prostate carcinoma. One of the main …

Abstract PI3K (phosphoinositide 3-kinase)/AKT and RAS/MAPK (mitogen-activated protein
kinase) pathway coactivation in the prostate epithelium promotes both epithelial …

Prostate cancer (PCa) is the second most common malignancy among men in the world.
Castration-resistant prostate cancer (CRPC) is the lethal form of the disease, which …

Radiation therapy (RT) is commonly used for the treatment of localized prostate cancer
(PCa). However, cancer cells often develop resistance to radiation through unknown …

Cancer stem cells (CSCs) in prostate cancer (CaP) are regarded as major contributors to
radioresistance due to complex mechanisms including enhanced DNA repair, increased …