Iron homeostasis and organismal aging
Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …
red blood cell function and many essential proteins and enzymes required for numerous …
Impaired iron status in aging research
J Xu, Z Jia, MD Knutson, C Leeuwenburgh - International journal of …, 2012 - mdpi.com
Aging is associated with disturbances in iron metabolism and storage. During the last
decade, remarkable progress has been made toward understanding their cellular and …
decade, remarkable progress has been made toward understanding their cellular and …
Iron metabolism in aging and age-related diseases
Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …
biological processes. Aging refers to the natural life process in which the physiological …
Iron and ageing: an introduction to iron regulatory mechanisms
CW Levenson, NM Tassabehji - Ageing research reviews, 2004 - Elsevier
While there have been significant advances made in our understanding of the cellular and
molecular mechanisms that regulate iron absorption, transport, storage, and utilization, the …
molecular mechanisms that regulate iron absorption, transport, storage, and utilization, the …
[HTML][HTML] Iron: An underrated factor in aging
D Mangan - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Iron is an essential element for virtually all living organisms, but its reactivity also makes it
potentially harmful. Iron accumulates with aging, and is associated with many age-related …
potentially harmful. Iron accumulates with aging, and is associated with many age-related …
The emerging role of iron dyshomeostasis in the mitochondrial decay of aging
J Xu, E Marzetti, AY Seo, JS Kim, TA Prolla… - Mechanisms of ageing …, 2010 - Elsevier
Recent studies show that cellular and mitochondrial iron increases with age. Iron overload,
especially in mitochondria, increases the availability of redox-active iron, which may be a …
especially in mitochondria, increases the availability of redox-active iron, which may be a …
Molecular regulation of cellular iron balance
Handling a life‐supporting yet redox‐active metal like iron represents a significant challenge
to cells and organisms that must not only tightly balance intra‐and extracellular iron …
to cells and organisms that must not only tightly balance intra‐and extracellular iron …
Age-dependent and gender-specific changes in mouse tissue iron by strain
Iron is necessary for life but also a potent pro-oxidant implicated in the pathogenesis of age-
related diseases. We sought to determine if iron levels change with age and by sex in …
related diseases. We sought to determine if iron levels change with age and by sex in …
Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
T Nakamura, I Naguro, H Ichijo - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
Background Iron is essential for many types of biological processes. However, excessive
iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron …
iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron …