Malaria diagnosis using paper-based immunoassay for clinical blood sampling and analysis by a miniature mass spectrometer

S Lee, DS Kulyk, SO Afriyie, K Badu… - Analytical …, 2022 - ACS Publications
In this work, we have developed a paper-based microfluidic device capable of remote
biofluid collection followed by an analysis of the dried clinical samples using a miniature …

Automated immunoassay performed on a 3D microfluidic paper-based device for malaria detection by ambient mass spectrometry

S Jackson, S Lee, AK Badu-Tawiah - Analytical chemistry, 2022 - ACS Publications
Microfluidic paper-based analytical devices (μPADs) are emerging as a prominent platform
for disease detection, specifically in developing countries. This paper device offer simplicity …

Single-step, paper-based concentration and detection of a malaria biomarker

DY Pereira, RYT Chiu, SCL Zhang, BM Wu… - Analytica Chimica …, 2015 - Elsevier
The lateral-flow immunoassay (LFA) is an inexpensive and rapid paper-based assay that
can potentially detect infectious disease biomarkers in resource-poor settings. Despite its …

Assessment of colorimetric amplification methods in a paper-based immunoassay for diagnosis of malaria

S Lathwal, HD Sikes - Lab on a Chip, 2016 - pubs.rsc.org
Colorimetric detection methods that produce results readable by eye are important for
diagnostic tests in resource-limited settings. In this work, we have compared three main …

A simple, sensitive and reduced cost paper-based device with low quantity of chemicals for the early diagnosis of Plasmodium falciparum malaria using an enzyme …

GP dos Santos, CC Corrêa, LT Kubota - Sensors and Actuators B …, 2018 - Elsevier
In this study, we report the development of a paper-based platform with low amount of
reagents for the detection of the histidine-rich protein 2 by an enzyme-based colorimetric …

Mass spectrometry for paper-based immunoassays: toward on-demand diagnosis

S Chen, Q Wan, AK Badu-Tawiah - Journal of the American …, 2016 - ACS Publications
Current analytical methods, either point-of-care or centralized detection, are not able to meet
recent demands of patient-friendly testing and increased reliability of results. Here, we …

A microfluidic paper analytical device using capture aptamers for the detection of PfLDH in blood matrices

AM Ogunmolasuyi, R Fogel, H Hoppe, D Goldring… - Malaria Journal, 2022 - Springer
Background The prevalence and death rate arising from malaria infection, and emergence
of other diseases showing similar symptoms to malaria require the development of malaria …

Rapid diagnosis and prognosis of malaria infection using a microfluidic point-of-care immunoassay

J Li, AM Saidi, K Seydel, PB Lillehoj - Biosensors and Bioelectronics, 2024 - Elsevier
Malaria is a major cause of illness and death worldwide. Rapid diagnostic tests are the most
widely used tool for detecting malaria infection, however, they only provide binary results …

Malaria quantitative POC testing using magnetic particles, a paper microfluidic device and a hand-held fluorescence reader

K Arias-Alpízar, A Sánchez-Cano, J Prat-Trunas… - Biosensors and …, 2022 - Elsevier
A point-of-care (POC) device is reported for highly sensitive and selective detection of
Plasmodium falciparum lactate dehydrogenase (Pf-LDH), a biomarker of malaria infection …

Sample-to-answer palm-sized nucleic acid testing device towards low-cost malaria mass screening

G Choi, T Prince, J Miao, L Cui, W Guan - Biosensors and Bioelectronics, 2018 - Elsevier
The effectiveness of malaria screening and treatment highly depends on the low-cost access
to the highly sensitive and specific malaria test. We report a real-time fluorescence nucleic …