Gene-expression profiling has had a considerable impact on our understanding of breast
cancer biology. During the last 15 years, 5 intrinsic molecular subtypes of breast cancer …

Gene expression profiling has had a considerable impact on our understanding of breast
cancer biology. During the last decade, 4 intrinsic molecular subtypes of breast cancer …

The last decade has brought a breakthrough in the knowledge of the biology of breast
cancer. The technological development, and in particular the high throughput technologies …

Breast cancer is a heterogeneous disease in terms of histology, therapeutic response,
dissemination patterns to distant sites, and patient outcomes. Global gene expression …

Gene expression profiling has led to a new molecular classification of breast cancer
characterized by four intrinsic subtypes: basal-like, HER2-positive, luminal A, and luminal B …

Abstract Introduction The St Gallen International Expert Consensus on the Primary Therapy
of Early Breast Cancer 2013 recognized substantial progress in the pathological …

Background Predicting treatment benefit and/or outcome before any therapeutic intervention
has taken place would be clinically very useful. Herein, we evaluate the ability of the intrinsic …

Purpose Chemotherapy has been the historical mainstay of treatment for patients with breast
cancer, with immunohistochemical markers and tumor characteristics driving treatment …

Gene expression profiling has led to the discovery of 4 distinct molecular subtypes of breast
cancer: luminal A, luminal B, basal like, and HER2 enriched. Investigation of these subtypes …

Background The clinical impact of the biological heterogeneity within HER2-positive
(HER2+) breast cancer is not fully understood. Here, we evaluated the molecular features …