Interleukin-6 (IL-6) is the major cytokine inducing transcription of human C-reactive protein
(CRP) during the acute phase response. STAT (signal transducers and activators of …

C-reactive protein (CRP) is synthesized in hepatocytes. The serum concentration of CRP
increases dramatically during the acute phase response. In human hepatoma Hep3B cells …

Transcription of C-reactive protein (CRP) in Hep 3B cells is induced by IL-6, acting through
C/EBP isoforms and STAT3. IL-1β, which alone has no effect, greatly enhances IL-6-induced …

Interleukin-4 (IL-4) is an anti-inflammatory cytokine which inhibits many inducible
macrophage functions. The present study demonstrates that the ability of IL-4 to inhibit …

Transcriptional activation of eukaryotic genes often requires the cooperative action of many
proteins. The interleukin 6 (IL-6) response element (IRE) is activated by signal transducer …

STAT3 (signal transducer and activator of transcription 3) is a key transcription factor
mediating the signals for a variety of cytokines, including interleukin-6 (IL-6). The Stat3 gene …

We have investigated the function of different mediators of the regulation of the human C-
reactive protein (hCRP) gene in transgenic mice. hCRP was induced by lipopolysaccharide …

To study the mechanism of interleukin-6 (IL-6) induction of human C-reactive protein (CRP)
gene expression, we have utilized a human hepatoma (PLC/PRF/5) cell culture system to …

We have previously found that overexpression of the Rel protein p50 stimulated C-reactive
protein (CRP) expression in Hep 3B cells and that p50 could bind to a nonconsensus κB site …

The combination of interleukin 6 (IL-6) and interleukin 1 (IL-1) synergistically induces the
human acute-phase reactant, C-reactive protein (CRP) in Hep3B cells. While previous …